WG Cellular Neurophysiology

We investigate signal transduction processes that control the activity of excitable cells.

We use cell and molecular biological and electrophysiological methods to identify and elucidate the signaling pathways and the related pathological changes.

In cooperation with university hospitals in Würzburg and Bielefeld, we are explicitly investigating the involvement of ion channels in particular in the development of neurological, cardiac and psychiatric symptoms. In the in vitro modeling of pathophysiology, we use patient-specific induced pluripotent stem cells, CRISPR-Cas9 technology and small molecule differentiation protocols to map the genetic background of patients in vitro. In the analysis, we focus on the investigation of sex-specific differences, whereby the aim of the research projects is always to elucidate the pathophysiology in order to use this as a basis for new therapy options.