Publications

Publications since 2017 of research groups participating in the network are listed below.
The scientists from the Stem Cell Network.NRW are marked in bold.

• Zink A, Conrad J, Telugu NS, Diecke S, Heinz A, Wanker E, Priller J, Prigione A (2020) Assessment of ethanol-induced toxicity on iPSC-derived human neurons using a novel high-throughput Mitochondrial Neuronal Health (MNH) assay Front. Cell Dev. Biol. Oct 15; doi: 10.3389/fcell.2020.590540
   
• Peischard S, Ho HT, Piccini I, Strutz-Seebohm N, Röpke A, Liashkovich I, Gosain H, Rieger B, Klingel K, Eggers B, Marcus K, Linke WA, Müller FU, Ludwig S, Greber B, Busch K, Seebohm G (2020)  The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus diseaseScientific Reports Oct 8; 10:16804
   
• Ramani A, Müller L, Ostermann PN, Gabriel E, Abida‐Islam P, Müller‐Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J (2020) SARS‐CoV‐2 targets neurons of 3D human brain organoids. EMBO J. Sep 2; doi:10.15252/embj.2020106230
   
• Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W (2020) PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. Clinical Epigenetics. Aug 20; 12, 125 
   
• Kim KP, Choi J, Yoon J, Bruder JM, Shin B, Kim J, Arauzo-Bravo MJ, Han D, Wu G, Wook Han D, Kim J, Cramer P, Schöler HR (2020) Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nat Chem Biol. Aug 17; doi: 10.1038/s41589-020-0618-6
   
• Steens J, Klar L, Hansel C, Slama A,  Hager T, Jendrossek V, Aigner C, Klein D (2020) The vascular nature of lung resident mesenchymal stem cells. Stem Cells Transl Med. Accepted/ In Press.
   
• Zipper L, Jassmann D, Burgmer S, Görlich B, Reiff T (2020) Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila. eLife. Aug 10; 9:e5579
   
• Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey JZ, Jeggo R, Jhamandas JH, Kann O, Mannoury la Cour C, Martin WF, Mithieux G, Moreira PI, Murphy MP, Nave KA, Nuriel T, Oliet SHR, Saudou F, Mattson MP, Swerdlow RH, Millan MJ.  (2020)Brain energy rescue: an emerging concept for new therapeutics in neurodegenerative disorders of aging.Nat Rev Drug Disc. Jul 24;19(9):609-633.
   
• Delgado-Benito V, Berruezo-Llacuna M, Altwasser R, Winkler W, Sundaravinayagam D, Balasubramanian S, Caganova M, Graf R, Rahjouei A, Henke M, Driesner M, Keller L, Prigione A, Janz M, Akalin A, Di Virgilio M (2020) Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.J Exp Med. 5;217(10):e20200137.
   
• Menacho C,Prigione A (2020) Tackling mitochondrial diversity in brain function: from animal models to human brain organoids. Int J Biochem Cell Biol. Jun;123:105760.
   
• Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J (2020) IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Int J Mol Sci. Jun 25; 21(12)
   
• Liedtke S, Korschgen L, Korn J, Duppers A, Kogler G (2020) GMP-grade CD34+ selection from HLA-homozygous licensed cord blood units and short-term expansion under European ATMP regulations. Vox Sang. Jun 20. doi: 10.1111/vox.12978.
   
• Peitz, M., Krutenko, T., Brüstle, O. (2020) Protocol for the standardized generation of forward programmed cryopreservable excitatory and inhibitory forebrain neurons.STAR Protocols (Cell Press) Jun 19; 1, 100038.
   
• Agrelo IS, Schira-Heinen J, Beyer F, Groh J, Bütermann C, Estrada V, Poschmann G, Bribian A, Jadasz JJ, Lopez-Mascaraque L, Kremer D, Martini R, Müller HW, Hartung HP, Adjaye J, Stühler K, Küry P (2020) Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Int J Mol Sci. Jun 18; 21(12)
   
• Flitsch, L.J., Laupman, K.E., Brüstle, O. (2020) Transcription factor-based fate specification and forward programming for neural regeneration.Front Cell Neurosci. May 20; 14, 121
   
• Bera S, Camblor-Perujo S, Barca EC, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J,  Kononenko N (2020) AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. EMBO Rep. April 23; 21(6).
   
• Klein D (2020) Improved Isolation of Human Vascular Wall-Resident Mesenchymal Stem Cells. Methods Mol Biol. May 2155:71-81.
   
• Steens J, Klump H, Klein D (2020) In Vitro Generation of Vascular Wall-Typical Mesenchymal Stem Cells (VW-MSC) from Murine Induced Pluripotent Stem Cells Through VW-MSC-Specific Gene Transfer. Methods Mol Biol. May 2155:83-97.
   
• Wang C, Börger V, Sardari M, Murke F, Skuljec J, Pul R, Hagemann N, Dzyubenko E, Dittrich R, Gregorius J, Hasenberg M, Kleinschnitz C, Popa-Wagner A, Doeppner TR, Gunzer M, Giebel B,Hermann DM (2020) Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils.Stroke, 51:1825–1834.
   
• Börger V, Weiss DJ, Anderson JD, Borras FE, Bussolati B, Carter DRF, Dominici M, Falcon-Perez JM, Gimona M, Hill AF, Hoffman AM, de Kleijn D, Levine BL, Lim R, Lotvall J, Mitsialis SA, Monguio-Tortajada M, Muraca M, Nieuwland R, Nowocin A, O’Driscoll L, Ortiz LA, Phinney DG, Reischl I, Rohde E, Sanzenbacher R, Thery C, Toh WS, Witwerv KW, Lim SK, Giebel B (2020) ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19, Cytotherapy. May 02; doi: 10.1016/j.jcyt.
   
• Katakam SK, Tria V, Sim W, George W. Yip GW, Molgora S, Karnavas T, Eslam A. Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B, Götte M (2020) The heparan sulfate proteoglycan Syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase – Wnt signaling axis. FEBS Journal. May 05; doi: 10.1111/FEBS.15356.
   
• Troschel FM, Minte A, Ismail YM, Kamal A, Abdullah MS, Ahmed SH, Deffner M, Kemper B, Kiesel L, Eich HT, Ibrahim SA, Götte M, Greve B (2020) Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer. Int. J. Mol. Sci. Mar 19; 21(6), 2169.
   
• Wruck W, Adjaye J (2020) Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. Acta Neuropathologica Communications. Mar 05; 8(1):26.
   
• Rahman S, Wruck W, Spitzhorn LS, Nguyen L, Bohndorf M, Martins S, Asar F, Ncube A, Erichsen L, Graffmann N , Adjaye J (2020) The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor Cells. Scientific Reports. Jan 20; 10, 739.
• Martinsen R, Gerhards H, Hoffmann F, Roth P (2020) Paradoxe Zukünfte. Eine narratologisch-empirische Analyse des Diskurswandels von Moral zu Risiko in der Stammzellforschung und ihren Anwendungen in Deutschland, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 128-183.
• Fangerau H, Gassner U, Martinsen R (2020) Chancen und Risiken der Stammzellforschung aus einer interdisziplinären Perspektive, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 3-11.
   
• Fangerau H, Gassner U, Martinsen R, Bittner U, Gerhards H, Hoffmann F, Opper J, Rolfes V, Roth P (2020) Politikempfehlungen zur Stammzellforschung auf der Basis  einer interdisziplinären Chancen- und Risikoanalyse, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 360-376.
   
• Hoffmann F (2020) Adulte Stammzellen im blinden Fleck des Diskurses. Anwendungsperspektiven eines konstruktivistischen Forschungsprogramms für die Technikfolgenabschätzung, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 200-231.