Publications

Publications since 2017 of research groups participating in the network are listed below.
The scientists from the Stem Cell Network NRW are marked in bold.

• Kimura K, Breitbach M, Schildberg FA, Hesse M, Fleischmann BK (2021) Bone marrow CD73+ mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo, Bone Reports Volume 15, December 2021

• Wruck W, Graffmann N, Spitzhorn L, Adjaye J (2021) Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity, Front. Cell Dev. Biol., September 2021

• Salewskij K, Gross-Thebing T, Ing-Simmons E, Duethorn B, Rieger B, Fan R, Chen R, Govindasamy N, Brinkmann H, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Stehling M, Dejosez M, Zwaka TP, Schöler HR, Busch KB, Vaquerizas JM, Bedzhov I (2021) Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development, EMBO Rep 2021

• Sentek H, Klein D (2021) Lung-Resident Mesenchymal Stem Cell Fates within Lung Cancer, Cancers 2021 

• Di Persio S, Tekath T, Siebert-Kuss LM, Cremers JF, Wistuba J, Li X, Meyer zu Hörste G, Drexler H C.A., Wyrwoll MJ, Tüttelmann F, Dugas M, Kliesch S, Schlatt S, Laurentino S, Neuhaus N (2021) Single-cell RNA-seq unravelsalterations of the human spermatogonial stem cellcompartment in patients with impaired spermatogenesis, Cell Reports Medicine, September 2021

• Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmüller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J(2021) Human brain organoids assemble functionally integrated bilateral optic vesicles, Cell Stem Cell, August 2021

• Skowron MA, Becker TK, Kurz L, Jostes S, Bremmer F, Fronhoffs F, Funke K, Wakileh GA, Müller MR, Burmeister A, Lenz T, Stefanski A, Stühler K, Petzsch P, Köhrer K, Altevogt P, Albers P, Kristiansen G, Schorle H, Nettersheim D (2021) The signal transducer CD24 suppresses the germ cellprogram and promotes an ectodermal rather thanmesodermal cell fate in embryonal carcinomas, Molecular Oncology 2021

• Troschel FM, Linsenmaier M, Borrmann K, Eich KT, Götte M, Greve B (2021) Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin’s Lymphoma Cells, Anticancer Research July 2021

• Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H (2021) High proliferation and delamination during skin epidermal stratification, Nature Communications 12, May 2021

• Marks D, Heinen N, Bachmann L, Meermeyer S, Werner M, Gallego L, Hemmerich P, Bader V, Winklhofer KF, Schröder E, Knauer SK, Müller T (2021) Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load, Acta Neuropathologica Communications 9, April 2021

• Ahmed SH, Espinoza-Sánchez NA, El-Damen A, Fahim SA, Badawy MA, Greve B, El-Shinawi M, Götte M, Ibrahim SA (2021) Small extracellular vesicle-encapsulated miR-181b-5p, miR-222-3p and let-7a-5p: Next generation plasma biopsy-based diagnostic biomarkers for inflammatory breast cancer. Plos One April 2021

• Kim KP, Li C, Bunina D, Jeong HW, Ghelman J, Yoon J, Shin B, Park H, Han DW, Zaugg JB, Kim J, Kuhlmann T, Adams RH, Noh KM, Goldman SA, Schöler HR (2021) Donor cell memory confers a metastable state of directly converted cells. Cell Stem Cell April 12, 2021

•  Thiebes AL, Uhl FE, Hauser M, Cornelissen CG, Jockenhoevel S, Weiss DJ (2021)Endoscopic atomization of mesenchymal stromal cells: in vitro study for local cell therapy of the lungs. Cytotherapy April 01, Volume 23, ISSUE 4, P293-300

• Inak G, Rybak-Wolf A, Prigione A (2021) Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome  Nat Commun 12, 1929

• Stanoev A, Schröter C, Koseska A (2021) Robustness and timing of cellular differentiation through population-based symmetry breaking Development Feb 15, 148: dev197608.
   
• Piotrowskia T, Rippel O, Elanzew A, Nießing B, Stucken S, Jung S, König N, Haupt S, Stappert L, Brüstle O, Schmitt R, Jonas S (2021) Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status.Comput Biol Med. Feb, 129:104172.
   
• Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J (2021) A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. Biology Open Jan 25; 10: bio054189 
   
• Wruck W, Bremmer F, Kotthoff M, Fichtner A, Skowron MA, Schönberger S, Calaminus G, Vokuhl C, Pfister D, Heidenreich A, Albers P, Adjaye J, Nettersheim D (2020) The pioneer and differentiation factor FOXA2 is a key driver of yolk‐sac tumour formation and a new biomarker for paediatric and adult yolk‐sac tumours. Journal of Cellular and Molecular Medicin Jan 14; 00:1–12
   
• Hassan N, Greve B, Espinoza-Sánchez NA, Martin Götte M (2021) Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer. Cellular Signalling Jan; Vol 77, 109822
   
• Cenini G, Hebisch M, Iefremova V, Flitsch LJ, Breitkreuz Y, Tanzi RE, Kim DY, Peitz M, Brüstle O (2020) Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models. Mol Cell Neurosci Jan; 14:103568. 

• Nouri, P., Götz, S., Rauser, B., Irmler, M., Peng, C., Trümbach, D., Kempny, C., Lechermeier, C.G., Bryniok, A., Dlugos, A., Euchner, E., Beckers, J., Brodski, C., Klümper, C., Wurst, W. and Prakash, N.(2020). Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling. Front. Cell Dev. Biol. 8, 587778.

• Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J (2020) A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. Biology Open Dec 28; doi: 10.1242/bio.05418Z
   
• Cheffer A, Flitsch LJ, Krutenko T, Röderer P, Sokhranyaeva L, Iefremova V, Hajo M, Peitz M, Schwarz MK, Brüstle O (2020) Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction. Mol Autism. Dec 11; 11(1):99. 
   
• Wruck W, Adjaye J (2020) SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress. Scientific Reports Dec 8; 10, 21415
   
• Ng AHM, Khoshakhlagh P, Arias JER, Pasquini G, Wang K, Swiersy A, Shipman SL, Appleton E, Kiaee K, Kohman RE, Vernet A, Dysart M, Leeper K, Saylor W, Huang JY, Graveline A, Taipale J, Hill DE, Vidal M, Melero-Martin JM, Busskamp V, Church GM (2020) A comprehensive library of human transcription factors for cell fate engineering. Nat Biotechnol Nov 30; dio: 10.1038/s41587-020-0742-6
   
• Elanzew A, Nießing B, Langendoerfer D, Rippel O, Piotrowski T, Schenk F, Kulik M, Peitz M, Breitkreuz Y, Jung S, Wanek P, Stappert L, Schmitt RH, Haupt S, Zenke M, König N, Brüstle O (2020) The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells. Front Bioeng Biotechnol. Nov 9; 8:580352. 
   
• Klein D (2020) Lung multipotent stem cells of mesenchymal nature: Cellular basis, clinical relevance and implications for stem cell therapy. Antioxid Redox Signal Nov 9; dio: 10.1089/ars.2020.8190
   
• Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, Leidel SA, Seebohm G, Schöler HR, Bruder JM (2020) A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. eLife Nov 3; doi: 10.7554/eLife.52904
   
• Gassner, Ulrich M. & Tade M. Spranger (2020): Stammzellen in Forschung und Therapie: Rechtsrahmen und Reformbedarf; Schriften zum Bio-, Gesundheits- und Medizinrecht; Band 43; Nomos.
   
• Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Schöler HR, Leidel SA, Ivan Bedzhov (2020) Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nat Commun. Oct 30; 11(1):5499.
   
• Tabari D, Scholl C, Steffens M, Weickhardt S, Elgner F, Bender D, Herrlein ML, Sabino C, Semkova V, Peitz M, Till A, Brüstle O, Hildt E, Stingl J (2020) Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures. Viruses. Oct 27;12(11):1219. 
   
• Mall EM, Rotte N, Yoon J, Sandhowe-Klaverkamp R, Röpke A, Wistuba J, Hübner K, Schöler HR, Schlatt S (2020) A novel xeno-organoid approach: exploring the crosstalk between human iPSC-derived PGC-like and rat testicular cells. Molecular Human Reproduction Oct 13; gaaa067,
   
• Zink A, Conrad J, Telugu NS, Diecke S, Heinz A, Wanker E, Priller J, Prigione A (2020) Assessment of ethanol-induced toxicity on iPSC-derived human neurons using a novel high-throughput Mitochondrial Neuronal Health (MNH) assay. Front. Cell Dev. Biol. Oct 15; doi: 10.3389/fcell.2020.590540
   
• Peischard S, Ho HT, Piccini I, Strutz-Seebohm N, Röpke A, Liashkovich I, Gosain H, Rieger B, Klingel K, Eggers B, Marcus K, Linke WA, Müller FU, Ludwig S, Greber B, Busch K, Seebohm G (2020)  The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease. Scientific Reports Oct 8; 10:16804
   
• Ponandai-Srinivasan S, Saare M, Boggavarapu NR, Frisendahl C, Ehrström S, Riethmüller C, García-Uribe PA, Rettkowski J, Iyengar A, Salumets A, Lalitkumar P, Götte M, Gemzell-Danielsson K (2020) Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. Hum Reprod. Oct 1; 35(10):2280-2293
   
• Teixeira F, Kumar AV, Katakam SK, Cocola C, Pelucchi P, Graf M, Kiesel L, Reinbold R, Pavão M,  Greve B, Götte M (2020) The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties. Front. Cell Dev. Biol., Sep 25;  doi:10.3389/fcell.2020.559554
   
• Krenn PW, Koschmieder S, Fässler R (2020) Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches. PNAS Sep 14; 117(39):24326-24335.
   
• Ramani A, Müller L, Ostermann PN, Gabriel E, Abida‐Islam P, Müller‐Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J (2020) SARS‐CoV‐2 targets neurons of 3D human brain organoids. EMBO J. Sep 2; doi:10.15252/embj.2020106230
   
• Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W (2020) PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. Clinical Epigenetics. Aug 20; 12, 125 
   
• Börschel CS, Stejskalova A, Schäfer SD, Kiesel L, Götte M (2020) miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function. Biomedicines Aug 18; 8(8), 291
   
• Kim KP, Choi J, Yoon J, Bruder JM, Shin B, Kim J, Arauzo-Bravo MJ, Han D, Wu G, Wook Han D, Kim J, Cramer P, Schöler HR (2020) Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nat Chem Biol. Aug 17; doi: 10.1038/s41589-020-0618-6
   
• Steens J, Klar L, Hansel C, Slama A,  Hager T, Jendrossek V, Aigner C, Klein D (2020) The vascular nature of lung resident mesenchymal stem cells. Stem Cells Transl Med. Accepted/ In Press.
   
• Zipper L, Jassmann D, Burgmer S, Görlich B, Reiff T (2020) Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila. eLife. Aug 10; 9:e5579
   
• Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey JZ, Jeggo R, Jhamandas JH, Kann O, Mannoury la Cour C, Martin WF, Mithieux G, Moreira PI, Murphy MP, Nave KA, Nuriel T, Oliet SHR, Saudou F, Mattson MP, Swerdlow RH, Millan MJ. (2020) Brain energy rescue: an emerging concept for new therapeutics in neurodegenerative disorders of aging. Nat Rev Drug Disc. Jul 24; 19(9):609-633.
   
• Kouwenberg M, Rops A,  Bakker-van Bebber M, Diepeveen L, Götte M, Hilbrands L, van der Vlag J (2020) Role of syndecan-1 in the interaction between dendritic cells and T cells. PLoS One. Jul 23; 15(7):e0230835.
   
• Ozguldez HO, Fan R, Bdzhov I (2020)  Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination. Development Jul 3; 147: dev190371 
   
• Delgado-Benito V, Berruezo-Llacuna M, Altwasser R, Winkler W, Sundaravinayagam D, Balasubramanian S, Caganova M, Graf R, Rahjouei A, Henke M, Driesner M, Keller L, Prigione A, Janz M, Akalin A, Di Virgilio M (2020) Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.J Exp Med. 5;217(10):e20200137.
   
• Menacho C,Prigione A (2020) Tackling mitochondrial diversity in brain function: from animal models to human brain organoids. Int J Biochem Cell Biol. Jun; 123:105760.
   
• Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J (2020) IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Int J Mol Sci. Jun 25; 21(12)
   
• Liedtke S, Korschgen L, Korn J, Duppers A, Kogler G (2020) GMP-grade CD34+ selection from HLA-homozygous licensed cord blood units and short-term expansion under European ATMP regulations. Vox Sang. Jun 20. doi: 10.1111/vox.12978.
   
• Peitz M, Krutenko T, Brüstle O (2020)Protocol for the standardized generation of forward programmed cryopreservable excitatory and inhibitory forebrain neurons.STAR Protocols (Cell Press) Jun 19; 1, 100038.
   
• Agrelo IS, Schira-Heinen J, Beyer F, Groh J, Bütermann C, Estrada V, Poschmann G, Bribian A, Jadasz JJ, Lopez-Mascaraque L, Kremer D, Martini R, Müller HW, Hartung HP, Adjaye J, Stühler K, Küry P (2020) Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Int J Mol Sci. Jun 18; 21(12)
   
• Manou D, Bouris P, Kletsas D, Götte M, Greve B, Moustakas A, Karamanos NK, Theocharis AD (2020) Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential. Matrix Biol Plus May, 11;6-7:100033.
   
• Flitsch LJ, Laupman KE, Brüstle O (2020)Transcription factor-based fate specification and forward programming for neural regeneration. Front Cell Neurosci. May 20; 14, 121
   
• Manou D, Bouris P, Kletsas D, Götte M, Greve B, Moustakas A, Karamanos NK, Theocharis AD (2020) Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential. Matrix Biology Plus. May, 6-7:100033
   
• Katakam SK, Pelucchi P, Cocola C, Reinbold R, Vlodavsky I, Greve B, Götte M (2020) Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells. Front Oncol. May 14; 10:774.
   
• Klein D (2020) Improved Isolation of Human Vascular Wall-Resident Mesenchymal Stem Cells. Methods Mol Biol. May 2155:71-81.
   
• Steens J, Klump H, Klein D (2020) In Vitro Generation of Vascular Wall-Typical Mesenchymal Stem Cells (VW-MSC) from Murine Induced Pluripotent Stem Cells Through VW-MSC-Specific Gene Transfer. Methods Mol Biol. May 2155:83-97.
   
• Wang C, Börger V, Sardari M, Murke F, Skuljec J, Pul R, Hagemann N, Dzyubenko E, Dittrich R, Gregorius J, Hasenberg M, Kleinschnitz C, Popa-Wagner A, Doeppner TR, Gunzer M, Giebel B,Hermann DM (2020) Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils.Stroke, 51:1825–1834.
   
• Börger V, Weiss DJ, Anderson JD, Borras FE, Bussolati B, Carter DRF, Dominici M, Falcon-Perez JM, Gimona M, Hill AF, Hoffman AM, de Kleijn D, Levine BL, Lim R, Lotvall J, Mitsialis SA, Monguio-Tortajada M, Muraca M, Nieuwland R, Nowocin A, O’Driscoll L, Ortiz LA, Phinney DG, Reischl I, Rohde E, Sanzenbacher R, Thery C, Toh WS, Witwerv KW, Lim SK, Giebel B (2020) ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19, Cytotherapy. May 02; doi: 10.1016/j.jcyt.
   
• Katakam SK, Tria V, Sim W, George W. Yip GW, Molgora S, Karnavas T, Eslam A. Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B, Götte M (2020) The heparan sulfate proteoglycan Syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase – Wnt signaling axis. FEBS Journal. May 05; doi: 10.1111/FEBS.15356.
   
• Bera S, Camblor-Perujo S, Barca EC, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J,  Kononenko N (2020) AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. EMBO Rep. April 23; 21(6).
   
• Troschel FM, Minte A, Ismail YM, Kamal A, Abdullah MS, Ahmed SH, Deffner M, Kemper B, Kiesel L, Eich HT, Ibrahim SA, Götte M, Greve B (2020) Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer. Int. J. Mol. Sci. Mar 19; 21(6), 2169.
   
• Wruck W, Adjaye J (2020) Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. Acta Neuropathologica Communications. Mar 05; 8(1):26.
   
• Rahman S, Wruck W, Spitzhorn LS, Nguyen L, Bohndorf M, Martins S, Asar F, Ncube A, Erichsen L, Graffmann N , Adjaye J (2020) The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor Cells. Scientific Reports. Jan 20; 10, 739.
• Martinsen R, Gerhards H, Hoffmann F, Roth P (2020) Paradoxe Zukünfte. Eine narratologisch-empirische Analyse des Diskurswandels von Moral zu Risiko in der Stammzellforschung und ihren Anwendungen in Deutschland, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 128-183.
   
• Fangerau H, Gassner U, Martinsen R (2020) Chancen und Risiken der Stammzellforschung aus einer interdisziplinären Perspektive, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 3-11.
   
• Fangerau H, Gassner U, Martinsen R, Bittner U, Gerhards H, Hoffmann F, Opper J, Rolfes V, Roth P (2020) Politikempfehlungen zur Stammzellforschung auf der Basis  einer interdisziplinären Chancen- und Risikoanalyse, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 360-376.
   
• Hoffmann F (2020) Adulte Stammzellen im blinden Fleck des Diskurses. Anwendungsperspektiven eines konstruktivistischen Forschungsprogramms für die Technikfolgenabschätzung, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 200-231.