Publications

Publications since 2017 of research groups participating in the network are listed below.
The scientists from the Stem Cell Network NRW are marked in bold.

2022

Bertillot F, Miroshnikova YA, Wickström SA (2022) Snapshot: Mechanotransduction in the nucleus, Cell

Burmeister A, Stephan A, Alves Avelar LA, Müller MR, Seiwert A, Höfmann S, Fischer F, Torres-Gomez H, Hoffmann MJ, Niegisch G, Bremmer F, Petzsch P, Köhrer K, Albers P, Kurz T, Skowron MA, Nettersheim D (2022) Establishment and evaluation of a dual HDAC / BET inhibitor as a therapeutic option for germ cell tumors and other urological malignancies, Molecular Cancer Therapeutics

Zink A, Haferkamp U, Wittich A, Beller M, Pless O, Prigione A (2022) High-content screening of mitochondrial polarization in neural cells derived from human pluripotent stem cells, STAR Protocols

Su Kim Y, Fan R, Lith SC, Dicke AK, Drexler HCA, Kremer L, Kuempel-Rink N, Hekking L, Stehling M, Bedzhov I (2022) Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition, Developmental Cell

Petese A, Fries FL, Broske B, Stumm R, Blaess S (2022) Lineage analysis of Cxcr4-expressing cells in the developing midbrain suggests that progressive competence restriction in dopaminergic progenitor cells contributes to the establishment of dopaminergic neuronal diversity, eNeuro

Rodriguez-Gatica JE, Iefremova V, Sokhranyaeva V, Au Yeung SWC, Breitkreuz Y, Brüstle O, Schwarz MK, Kubitscheck U (2022) Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development, Development, Volume 149

Riecks J, Parnigoni A, Győrffy B, Kiesel L, Passi A, Vigetti D, Götte M (2022) The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer, Journal of Cancer Research and Clinical Oncology

Mabrouk MHE, Goetzke R, Abagnale G, Yesilyurt B, Salz L, Cypris O, Glück P, Liesenfelder S, Zeevaert K, Ma Z, Toledo MAS, Li R, Costa IG, Lampert A, Pachauri V, Schnakenberg U, Zenke M, Wagner W (2022) The spatial self-organization within pluripotent stem cell colonies is continued in detaching aggregates, Biomaterials Volume 282, March 2022

Cypris O, Franzen J, Frobel J, Glück P, Kuo CC, Schmitz S, Nüchtern S, Zenke M, Wagner W (2022) Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation, BMC Biology volume 20, Article number: 141

Gasparini SJ, Tessmer K, Reh M, Wieneke S, Carido M, Völkner M, Borsch O, Swiersy A, Zuzic M, Goureau O, Kurth T, Busskamp V, Zeck G, Karl MO, Ader M (2022) Transplanted human cones incorporate into the retina and function in a murine cone degeneration model, JCI - The Journal of Clinic Investigation

Nguyen T, Ramachandran H, Martins S, Krutmann J, Rossi A (2022) Identification of genome edited cells using CRISPRnano, Nucleic Acids Research, gkac440, 30 May 2022

Falke I, Troschel FM, Palenta H, Löblein MT, Brüggemann K, Borrmann K, Eich HT, Götte M & Greve B (2022) Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation, Stem Cell Research & Therapy volume 13, Article number: 212 (2022)

Zuzic M, Striebel J, Pawlick JS, Sharma K, Holz FG, Busskamp V (2022) Gene-independent therapeutic interventions to maintain and restore light sensitivity in degenerating photoreceptors, Progress in Retinal and Eye Research, 11 May 2022, 101065

Graffmann N, Scherera B, Adjaye J (2022) In vitro differentiation of pluripotent stem cells into hepatocyte like cells – Basic principles and current progress, Stem Cell Research Volume 61, May 2022

Zipper L, Batchu S, Kaya NH, Antonello ZA, Reiff T (2022) The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells, Metabolites 2022, 12(4), 315

Nguyen L, Wruck W, Erichsen L, Graffmann N, Adjaye J (2022) The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells, Cells 2022, 11(4), 635

Nouri P, Zimmer A, Brüggemann S, Friedrich R, Kühn R, Prakash N (2022) Generation of a NES-mScarlet Red Fluorescent Reporter Human iPSC Line for Live Cell Imaging and Flow Cytometric Analysis and Sorting Using CRISPR-Cas9-Mediated Gene Editing, Cells Volume 11, Issue 1, January 13

2021

Tolve M, Ulusoy A, Patikas N, Islam KUS, Bodea G, Öztürk E, Broske B, Mentani A, Wagener A, van Loo KMJ, Britsch S, Liu P, Khaled WT, Metzakopian E, Baader SL, Di Monte DA, Blaess S (2021) The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons, Cell Reports 36, 2021

Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, Riedel Y, Becker M, Händler K, Elmzzahi T, Bassler K, Reusch N, Yeghiazarian LH, Pecht T, Saglam A, Ulas T, Aschenbrenner AC, Kaiser F, Kubaczka C, Schultze JL, Schorle H (2021) Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs, Nature Communications 12, 2021

Govindasamy N, Long H, Jeong HW, Raman R, Özcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I (2021) 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels, Developmental Cell 2021, November 5

Raina D, Bahadori A, Stanoev A, Protzek M, Koseska A, Schröter C (2021) Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells, Development 2021, November 1

Kniebs C, Luengen AE, Guenther D, Cornelissen CG, Schmitz-Rode T, Jockenhoevel S, Thiebes AL (2021) Establishment of a Pre-vascularized 3D Lung Cancer Model in Fibrin Gel—Influence of Hypoxia and Cancer-Specific Therapeutics, Frontiers in Bioengineering and Biotechnology, 14 October 2021

Bachmann S, Linde J, Bell M, Spehr M, Zempel H, Zimmer-Bensch G (2021) DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons, International Journal of Molecular Sciences 2021, 22(4), 2034

Kimura K, Breitbach M, Schildberg FA, Hesse M, Fleischmann BK (2021) Bone marrow CD73+ mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo, Bone Reports Volume 15, December 2021

Wruck W, Graffmann N, Spitzhorn L, Adjaye J (2021) Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity, Front. Cell Dev. Biol., September 2021

Salewskij K, Gross-Thebing T, Ing-Simmons E, Duethorn B, Rieger B, Fan R, Chen R, Govindasamy N, Brinkmann H, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Stehling M, Dejosez M, Zwaka TP, Schöler HR, Busch KB, Vaquerizas JM, Bedzhov I (2021) Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development, EMBO Rep 2021

Sentek H, Klein D (2021) Lung-Resident Mesenchymal Stem Cell Fates within Lung Cancer, Cancers 2021

Di Persio S, Tekath T, Siebert-Kuss LM, Cremers JF, Wistuba J, Li X, Meyer zu Hörste G, Drexler H C.A., Wyrwoll MJ, Tüttelmann F, Dugas M, Kliesch S, Schlatt S, Laurentino S, Neuhaus N (2021) Single-cell RNA-seq unravelsalterations of the human spermatogonial stem cellcompartment in patients with impaired spermatogenesis, Cell Reports Medicine, September 2021

Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmüller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J(2021) Human brain organoids assemble functionally integrated bilateral optic vesicles, Cell Stem Cell, August 2021

Skowron MA, Becker TK, Kurz L, Jostes S, Bremmer F, Fronhoffs F, Funke K, Wakileh GA, Müller MR, Burmeister A, Lenz T, Stefanski A, Stühler K, Petzsch P, Köhrer K, Altevogt P, Albers P, Kristiansen G, Schorle H, Nettersheim D (2021) The signal transducer CD24 suppresses the germ cellprogram and promotes an ectodermal rather thanmesodermal cell fate in embryonal carcinomas, Molecular Oncology 2021

Troschel FM, Linsenmaier M, Borrmann K, Eich KT, Götte M, Greve B (2021) Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin’s Lymphoma Cells, Anticancer Research July 2021

Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H (2021) High proliferation and delamination during skin epidermal stratification, Nature Communications 12, May 2021

Marks D, Heinen N, Bachmann L, Meermeyer S, Werner M, Gallego L, Hemmerich P, Bader V, Winklhofer KF, Schröder E, Knauer SK, Müller T (2021) Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load, Acta Neuropathologica Communications 9, April 2021

Ahmed SH, Espinoza-Sánchez NA, El-Damen A, Fahim SA, Badawy MA, Greve B, El-Shinawi M, Götte M, Ibrahim SA (2021) Small extracellular vesicle-encapsulated miR-181b-5p, miR-222-3p and let-7a-5p: Next generation plasma biopsy-based diagnostic biomarkers for inflammatory breast cancer. Plos One April 2021

Kim KP, Li C, Bunina D, Jeong HW, Ghelman J, Yoon J, Shin B, Park H, Han DW, Zaugg JB, Kim J, Kuhlmann T, Adams RH, Noh KM, Goldman SA, Schöler HR (2021) Donor cell memory confers a metastable state of directly converted cells. Cell Stem Cell April 12, 2021

Thiebes AL, Uhl FE, Hauser M, Cornelissen CG, Jockenhoevel S, Weiss DJ (2021)Endoscopic atomization of mesenchymal stromal cells: in vitro study for local cell therapy of the lungs. Cytotherapy April 01, Volume 23, ISSUE 4, P293-300

Inak G, Rybak-Wolf A, Prigione A (2021) Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome Nat Commun 12, 1929

Stanoev A, Schröter C, Koseska A (2021) Robustness and timing of cellular differentiation through population-based symmetry breaking Development Feb 15, 148: dev197608.
Piotrowskia T, Rippel O, Elanzew A, Nießing B, Stucken S, Jung S, König N, Haupt S, Stappert L, Brüstle O, Schmitt R, Jonas S (2021) Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status.Comput Biol Med. Feb, 129:104172.
Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J (2021) A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. Biology Open Jan 25; 10: bio054189
Wruck W, Bremmer F, Kotthoff M, Fichtner A, Skowron MA, Schönberger S, Calaminus G, Vokuhl C, Pfister D, Heidenreich A, Albers P, Adjaye J, Nettersheim D (2020) The pioneer and differentiation factor FOXA2 is a key driver of yolk‐sac tumour formation and a new biomarker for paediatric and adult yolk‐sac tumours. Journal of Cellular and Molecular Medicin Jan 14; 00:1–12
Hassan N, Greve B, Espinoza-Sánchez NA, Martin Götte M (2021) Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer. Cellular Signalling Jan; Vol 77, 109822
Cenini G, Hebisch M, Iefremova V, Flitsch LJ, Breitkreuz Y, Tanzi RE, Kim DY, Peitz M, Brüstle O (2020) Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models. Mol Cell Neurosci Jan; 14:103568.

2020

Nouri, P., Götz, S., Rauser, B., Irmler, M., Peng, C., Trümbach, D., Kempny, C., Lechermeier, C.G., Bryniok, A., Dlugos, A., Euchner, E., Beckers, J., Brodski, C., Klümper, C., Wurst, W. and Prakash, N.(2020). Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling. Front. Cell Dev. Biol. 8, 587778.

Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J (2020) A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. Biology Open Dec 28; doi: 10.1242/bio.05418Z
Cheffer A, Flitsch LJ, Krutenko T, Röderer P, Sokhranyaeva L, Iefremova V, Hajo M, Peitz M, Schwarz MK, Brüstle O (2020) Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction. Mol Autism. Dec 11; 11(1):99.
Wruck W, Adjaye J (2020) SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress. Scientific Reports Dec 8; 10, 21415
Ng AHM, Khoshakhlagh P, Arias JER, Pasquini G, Wang K, Swiersy A, Shipman SL, Appleton E, Kiaee K, Kohman RE, Vernet A, Dysart M, Leeper K, Saylor W, Huang JY, Graveline A, Taipale J, Hill DE, Vidal M, Melero-Martin JM, Busskamp V, Church GM (2020) A comprehensive library of human transcription factors for cell fate engineering. Nat Biotechnol Nov 30; dio: 10.1038/s41587-020-0742-6
Elanzew A, Nießing B, Langendoerfer D, Rippel O, Piotrowski T, Schenk F, Kulik M, Peitz M, Breitkreuz Y, Jung S, Wanek P, Stappert L, Schmitt RH, Haupt S, Zenke M, König N, Brüstle O (2020) The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells. Front Bioeng Biotechnol. Nov 9; 8:580352.
Klein D (2020) Lung multipotent stem cells of mesenchymal nature: Cellular basis, clinical relevance and implications for stem cell therapy. Antioxid Redox Signal Nov 9; dio: 10.1089/ars.2020.8190
Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, Leidel SA, Seebohm G, Schöler HR, Bruder JM (2020) A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. eLife Nov 3; doi: 10.7554/eLife.52904
Gassner, Ulrich M. & Tade M. Spranger (2020): Stammzellen in Forschung und Therapie: Rechtsrahmen und Reformbedarf; Schriften zum Bio-, Gesundheits- und Medizinrecht; Band 43; Nomos.
Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Schöler HR, Leidel SA, Ivan Bedzhov (2020) Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nat Commun. Oct 30; 11(1):5499.
Tabari D, Scholl C, Steffens M, Weickhardt S, Elgner F, Bender D, Herrlein ML, Sabino C, Semkova V, Peitz M, Till A, Brüstle O, Hildt E, Stingl J (2020) Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures. Viruses. Oct 27;12(11):1219.
Mall EM, Rotte N, Yoon J, Sandhowe-Klaverkamp R, Röpke A, Wistuba J, Hübner K, Schöler HR, Schlatt S (2020) A novel xeno-organoid approach: exploring the crosstalk between human iPSC-derived PGC-like and rat testicular cells. Molecular Human Reproduction Oct 13; gaaa067,
Zink A, Conrad J, Telugu NS, Diecke S, Heinz A, Wanker E, Priller J, Prigione A (2020) Assessment of ethanol-induced toxicity on iPSC-derived human neurons using a novel high-throughput Mitochondrial Neuronal Health (MNH) assay. Front. Cell Dev. Biol. Oct 15; doi: 10.3389/fcell.2020.590540
Peischard S, Ho HT, Piccini I, Strutz-Seebohm N, Röpke A, Liashkovich I, Gosain H, Rieger B, Klingel K, Eggers B, Marcus K, Linke WA, Müller FU, Ludwig S, Greber B, Busch K, Seebohm G (2020) The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease. Scientific Reports Oct 8; 10:16804
Ponandai-Srinivasan S, Saare M, Boggavarapu NR, Frisendahl C, Ehrström S, Riethmüller C, García-Uribe PA, Rettkowski J, Iyengar A, Salumets A, Lalitkumar P, Götte M, Gemzell-Danielsson K (2020) Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. Hum Reprod. Oct 1; 35(10):2280-2293
Teixeira F, Kumar AV, Katakam SK, Cocola C, Pelucchi P, Graf M, Kiesel L, Reinbold R, Pavão M, Greve B, Götte M (2020) The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties. Front. Cell Dev. Biol., Sep 25; doi:10.3389/fcell.2020.559554
Krenn PW, Koschmieder S, Fässler R (2020) Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches. PNAS Sep 14; 117(39):24326-24335.
Ramani A, Müller L, Ostermann PN, Gabriel E, Abida‐Islam P, Müller‐Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J (2020) SARS‐CoV‐2 targets neurons of 3D human brain organoids. EMBO J. Sep 2; doi:10.15252/embj.2020106230
Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W (2020) PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. Clinical Epigenetics. Aug 20; 12, 125
Börschel CS, Stejskalova A, Schäfer SD, Kiesel L, Götte M (2020) miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function. Biomedicines Aug 18; 8(8), 291
Kim KP, Choi J, Yoon J, Bruder JM, Shin B, Kim J, Arauzo-Bravo MJ, Han D, Wu G, Wook Han D, Kim J, Cramer P, Schöler HR (2020) Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nat Chem Biol. Aug 17; doi: 10.1038/s41589-020-0618-6
Steens J, Klar L, Hansel C, Slama A, Hager T, Jendrossek V, Aigner C, Klein D (2020) The vascular nature of lung resident mesenchymal stem cells. Stem Cells Transl Med. Accepted/ In Press.
Zipper L, Jassmann D, Burgmer S, Görlich B, Reiff T (2020) Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila. eLife. Aug 10; 9:e5579
Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey JZ, Jeggo R, Jhamandas JH, Kann O, Mannoury la Cour C, Martin WF, Mithieux G, Moreira PI, Murphy MP, Nave KA, Nuriel T, Oliet SHR, Saudou F, Mattson MP, Swerdlow RH, Millan MJ. (2020) Brain energy rescue: an emerging concept for new therapeutics in neurodegenerative disorders of aging. Nat Rev Drug Disc. Jul 24; 19(9):609-633.
Kouwenberg M, Rops A, Bakker-van Bebber M, Diepeveen L, Götte M, Hilbrands L, van der Vlag J (2020) Role of syndecan-1 in the interaction between dendritic cells and T cells. PLoS One. Jul 23; 15(7):e0230835.
Ozguldez HO, Fan R, Bdzhov I (2020) Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination. Development Jul 3; 147: dev190371
Delgado-Benito V, Berruezo-Llacuna M, Altwasser R, Winkler W, Sundaravinayagam D, Balasubramanian S, Caganova M, Graf R, Rahjouei A, Henke M, Driesner M, Keller L, Prigione A, Janz M, Akalin A, Di Virgilio M (2020) Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.J Exp Med. 5;217(10):e20200137.
Menacho C,Prigione A (2020) Tackling mitochondrial diversity in brain function: from animal models to human brain organoids. Int J Biochem Cell Biol. Jun; 123:105760.
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J (2020) IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Int J Mol Sci. Jun 25; 21(12)
Liedtke S, Korschgen L, Korn J, Duppers A, Kogler G (2020) GMP-grade CD34+ selection from HLA-homozygous licensed cord blood units and short-term expansion under European ATMP regulations. Vox Sang. Jun 20. doi: 10.1111/vox.12978.
Peitz M, Krutenko T, Brüstle O (2020)Protocol for the standardized generation of forward programmed cryopreservable excitatory and inhibitory forebrain neurons.STAR Protocols (Cell Press) Jun 19; 1, 100038.
Agrelo IS, Schira-Heinen J, Beyer F, Groh J, Bütermann C, Estrada V, Poschmann G, Bribian A, Jadasz JJ, Lopez-Mascaraque L, Kremer D, Martini R, Müller HW, Hartung HP, Adjaye J, Stühler K, Küry P (2020) Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Int J Mol Sci. Jun 18; 21(12)
Manou D, Bouris P, Kletsas D, Götte M, Greve B, Moustakas A, Karamanos NK, Theocharis AD (2020) Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential. Matrix Biol Plus May, 11;6-7:100033.
Flitsch LJ, Laupman KE, Brüstle O (2020)Transcription factor-based fate specification and forward programming for neural regeneration. Front Cell Neurosci. May 20; 14, 121
Manou D, Bouris P, Kletsas D, Götte M, Greve B, Moustakas A, Karamanos NK, Theocharis AD (2020) Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential. Matrix Biology Plus. May, 6-7:100033
Katakam SK, Pelucchi P, Cocola C, Reinbold R, Vlodavsky I, Greve B, Götte M (2020) Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells. Front Oncol. May 14; 10:774.
Klein D (2020) Improved Isolation of Human Vascular Wall-Resident Mesenchymal Stem Cells. Methods Mol Biol. May 2155:71-81.
Steens J, Klump H, Klein D (2020) In Vitro Generation of Vascular Wall-Typical Mesenchymal Stem Cells (VW-MSC) from Murine Induced Pluripotent Stem Cells Through VW-MSC-Specific Gene Transfer. Methods Mol Biol. May 2155:83-97.
Wang C, Börger V, Sardari M, Murke F, Skuljec J, Pul R, Hagemann N, Dzyubenko E, Dittrich R, Gregorius J, Hasenberg M, Kleinschnitz C, Popa-Wagner A, Doeppner TR, Gunzer M, Giebel B,Hermann DM (2020) Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils.Stroke, 51:1825–1834.
Börger V, Weiss DJ, Anderson JD, Borras FE, Bussolati B, Carter DRF, Dominici M, Falcon-Perez JM, Gimona M, Hill AF, Hoffman AM, de Kleijn D, Levine BL, Lim R, Lotvall J, Mitsialis SA, Monguio-Tortajada M, Muraca M, Nieuwland R, Nowocin A, O’Driscoll L, Ortiz LA, Phinney DG, Reischl I, Rohde E, Sanzenbacher R, Thery C, Toh WS, Witwerv KW, Lim SK, Giebel B (2020) ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19, Cytotherapy. May 02; doi: 10.1016/j.jcyt.
Katakam SK, Tria V, Sim W, George W. Yip GW, Molgora S, Karnavas T, Eslam A. Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B, Götte M (2020) The heparan sulfate proteoglycan Syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase – Wnt signaling axis. FEBS Journal. May 05; doi: 10.1111/FEBS.15356.
Bera S, Camblor-Perujo S, Barca EC, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J, Kononenko N (2020) AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. EMBO Rep. April 23; 21(6).
Troschel FM, Minte A, Ismail YM, Kamal A, Abdullah MS, Ahmed SH, Deffner M, Kemper B, Kiesel L, Eich HT, Ibrahim SA, Götte M, Greve B (2020) Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer. Int. J. Mol. Sci. Mar 19; 21(6), 2169.
Wruck W, Adjaye J (2020) Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. Acta Neuropathologica Communications. Mar 05; 8(1):26.
Rahman S, Wruck W, Spitzhorn LS, Nguyen L, Bohndorf M, Martins S, Asar F, Ncube A, Erichsen L, Graffmann N , Adjaye J (2020) The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor Cells. Scientific Reports. Jan 20; 10, 739.
Martinsen R, Gerhards H, Hoffmann F, Roth P (2020) Paradoxe Zukünfte. Eine narratologisch-empirische Analyse des Diskurswandels von Moral zu Risiko in der Stammzellforschung und ihren Anwendungen in Deutschland, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 128-183.
Fangerau H, Gassner U, Martinsen R (2020) Chancen und Risiken der Stammzellforschung aus einer interdisziplinären Perspektive, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 3-11.
Fangerau H, Gassner U, Martinsen R, Bittner U, Gerhards H, Hoffmann F, Opper J, Rolfes V, Roth P (2020) Politikempfehlungen zur Stammzellforschung auf der Basis einer interdisziplinären Chancen- und Risikoanalyse, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 360-376.
Hoffmann F (2020) Adulte Stammzellen im blinden Fleck des Diskurses. Anwendungsperspektiven eines konstruktivistischen Forschungsprogramms für die Technikfolgenabschätzung, in: Opper J, Roth P und Rolfes V (2020), Chancen und Risiken der Stammzellforschung, Berliner Wissenschafts-Verlag, 200-231.

2019

Brodski, C., Blaess, S., Partanen, J. and Prakash, N.(2019). Crosstalk of intercellular signaling pathways in the generation of midbrain dopaminergic neurons in vivo and from stem cells. J Dev. Biol. 7, 3.

Gopalakrishnan J (2019) The Emergence of Stem Cell‐Based Brain Organoids: Trends and Challenges. Bioessays. Aug 41(8) doi: 10.1002/bies.201900011.
Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, Weiss DJ, Zheng L, Giebel B, Lim SK (2019) Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles 8, 1609206.
Radtke S, Görgens A, da Conceicao Castro SV, Kordelas L, Köninger A, Dürig J, Möllmann M, Horn PA, Giebel B (2019) Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice.Scientific reports 9, 12914.
Görgens A, Bremer M, Ferrer-Tur R, Murke F, Tertel T, Horn PA, Thalmann S, Welsh JA, Probst C, Guerin C, Boulanger CM, Jones JC, Hanenberg H, Erdbrugger U, Lannigan J, Ricklefs FL, El-Andaloussi S, Giebel B (2019) Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material. J Extracell Vesicles 8, 1587567.
Giebel B, Hermann DM (2019) Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke. Ann Transl Med 7, 188.
Fangerau H, Martinsen R, Gassner U: (2019) Schlussbericht des BMBF-Forschungsprojekts „Multiple Risiken. Kontingenzbewältigung in der Stammzellforschung und ihren Anwendungen“ Heinrich-Heine-Universität Düsseldorf, Institut für Geschichte, Theorie und Ethik der Medizin, doi: 10.2314/KXP:1691950122.
Kniebs C, Kreimendahl F, Köpf M, Fischer H, Jockenhoevel S, Thiebes AL (2019) Influence of Different Cell Types and Sources on Pre-Vascularisation in Fibrin and Agarose–Collagen Gels. Organogenesis. Dec 6:1-13, doi: 10.1080/15476278.2019.1697597.
Steens J, Unger K, Klar L, Neureiter A, Wieber K, Hess J, Jakob HG, Klump H, Klein D (2019) Direct conversion of human fibroblasts into therapeutically active vascular wall‑typical mesenchymal stem cells. Cellular and Molecular Life Sciences. Nov 11,doi: 10.1007/s00018-019-03358-0.
Jungbluth P, Spitzhorn LS, Grassmann J, Tanner S, Latz D, Rahman MS, Bohndorf M, Wruck W, Sager M, Grotheer V, Kröpil P, Hakimi M, Windolf J, Schneppendahl J, Adjaye J (2019) Human iPSC-derived iMSCs improve bone regeneration in mini-pigs. Bone Research. Oct 7:32.
Han Y, Franzen J, Stiehl T, Gobs M, Kuo C, Nikolić M, Hapala J, Elisabeth Koop B, Strathmann K, Ritz‐Timme S, Wagner W (2019) New Targeted Approaches for Epigenetic Age Predictions. bioRxiv. doi: 10.1101/799031.
Radtke S, Görgens A, da Conceição Castro SV, Kordelas L, Köninger A, Dürig J, Möllmann M, Horn PA, Giebel B (2019) Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice. Scientific Reports. Sep 9;9(1):12914.
Kordelas L, Görgens A, Radtke S, Horn PA, Beelen DW, Giebel B (2019) Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows. Bone Marrow Transplantation. doi: 10.1038/s41409-019-0645-7.
Ostermann L, Ladewig J, Müller FJ, Kesevan J, Tailor J, Smith A, Brüstle O, Koch P (2019) In vitro recapitulation of developmental transitions in human neural stem cells. Stem Cells. Jul 24. doi: 10.1002/stem.3065.
Rehbach K, Kesavan J, Hauser S, Ritzenhofen S, Jungverdorben J, Schüle R, Schöls L, Peitz M, Brüstle O (2019) Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. Scientific Reports. Jul 9: 9615.
Vitale D, Kumar Katakam S, Greve B, Jang B, Oh ES, Alaniz L, Götte M (2019) Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance. FEBS Journal. Jun 23. doi: 10.1111/febs.14967.
Roth PH, Gerhards H (2019) Es ist nicht alles Gold, was glänzt… Die politische Rhetorik des ‚Goldstandards‘ und die diskursive Legitimierung der humanen embryonalen Stammzellforschung in Deutschland. In: Zeitschrift für Politik 66 (2): 143-164.
Blaschke S, Vay SU, Pallast N, Rabenstein M, Abraham JA, Linnartz C, Hoffmann M, Hersch N, Merkel R, Hoffmann B, Fink GR, Rueger MA (2019). Substrate elasticity induces quiescence and promotes neurogenesis of primary neural stem cells - a biophysical in vitro model of the physiological cerebral milieu. J Tissue Eng Regen Med. Jun 13 (6):960-972.
Meents JE, Bressan E, Sontag S, Foerster A, Hautvast P, Rösseler C, Hampl M, Schüler H, Goetzke R, Le TKC, Kleggetveit IP, Le Cann K, Kerth C, Rush AM, Rogers M, Kohl Z, Schmelz M, Wagner W, Jørum E, Namer B, Winner B, Zenke M, Lampert A (2019) The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Pain. Jun 160 (6):1327-1341.
Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, Peitz M, Toonen RF, Brüstle O, Verhage M (2019) A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons. Cell Reports. 27 (7): 2199-2211.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, Brose N, Brüstle O, Rhee JS (2019) An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons. Cell Reports. 27 (7): 2212-2228.
Spitzhorn LS, Megges M, Wruck W, Rahman MS, Otte J, Degistirici Ö, Meisel R, Sorg RV, Oreffo ROC, Adjaye J (2019) Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. Stem Cell Research & Therapy. 10(1):100.
Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling J, Dodzian J, Lagerborg KA, Vargas N, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano D, Kurian L (2019) Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Reports. Apr 20 (4).
Kuo CC, Hänzelmann S, Sentürk Cetin N, Frank S, Zajzon B, Derks JP, Akhade VS, Ahuja G, Kanduri C, Grummt I, Kurian L, Costa IG (2019) Detection of RNA-DNA binding sites in long noncoding RNAs. Nucleic Acids Res. Apr 8;47(6):e32.
El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR (2019) Genetic compensation triggered by mutant mRNA degradation. Nature. Apr 3 ;568(7751):193-197
Kordelas L, Schwich E, Dittrich R, Horn PA, Beelen DW, Börger V, Giebel B, Rebmann V (2019) Individual Immune-Modulatory Capabilities of MSC-Derived Extracellular Vesicle (EV) Preparations and Recipient-Dependent Responsiveness. International Journal of Molecular Sciences. Apr 2;20(7). pii: e1642.
Sauter EJ, Kutsche LK, Klapper SD, Busskamp V (2019) Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders. Methods Mol Biol. 1942:101-121.
Vaswani AR, Weykopf B, Hagemann C, Fried HU, Brüstle O, Blaess S (2019) Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons.Elife. Jan 28 (8). pii: e41623.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2019) yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell. Feb 7;24(2):318-327.e8.
Weykopf B , Haupt S , Jungverdorben J , Flitsch LJ., Hebisch M , Liu G , Suzuki K , Belmonte, JC., Peitz M , Blaess, S , Till, A, Brüstle, O (2019) Induced pluripotent stem cell‐based modeling of mutant LRRK2‐associated Parkinson's Disease. European Journal of Neuroscience. Jan 49 (4): 561– 589.
Jarocki M, Sallouh O, Weberskirch R, Faissner A. (2019) The Tenascin-C-Derived Peptide VSWRAPTA Promotes Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro.Mol Neurobiol. Jan 56 (1):632-647.

2018

Jovanovic, V.M., Salti, A., Tilleman, H., Zega, K., Jukic, M.M., Zou, H., Friedel, R.H., Prakash, N., Blaess, S., Edenhofer, F. and Brodski, C. (2018). BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells. J Neurosci. 38, 1662-1676.

Ludwig AK, De Miroschedji K, Doeppner TR, Börger V, Ruesing J, Rebmann V, Durst S, Jansen S, Bremer M, Behrmann E, Singer BB, Jastrow H, Kuhlmann JD, El Magraoui F, Meyer HE, Hermann DM, Opalka B, Raunser S, Epple M, Horn PA, Giebel B (2018) Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales. J Extracell Vesicles 7, 1528109.
Namer B, Schmidt D, Eberhardt E, Maroni M, Dorfmeister E, Kleggetveit IP, Kaluza L, Meents J, Gerlach A, Lin Z, Winterpacht A, Dragicevic E, Kohl Z, Schüttler J, Kurth I, Warncke T, Jorum E, Winner B, Lampert A (2018) Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors. EBioMedicine. Nov 28. pii: S2352-3964(18)30546-2.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2018) yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs, Cell Stem Cell, Nov 21. pii: S1934-5909(18)30541-1.
Gerhards H und Martinsen R (2018) Vom ethischen Frame zum Risikodispositiv: Der gewandelte Diskurs zur Stammzellforschung und ihren Anwendungen, in: Martinsen R und Niederberger A (2018) Risikoforschung, UNIKATE, Ausgabe 52, 68-81.
Niemietz C, Fleischhauer L, Sandfort V, Guttmann S, Zibert A, Schmidt HH (2018) Hepatocyte-like cells reveal novel role of SERPINA1 in transthyretin amyloidosis.J Cell Sci. Nov 26;131(23). pii: jcs219824.
Böke F, Labude N, Lauria I, Ernst S, Müller-Newen G, Neuss S, Fischer H (2018) Biological Activation of Bioinert Medical High Performance Oxide Ceramics by Hydrolytically Stable Immobilization of c(RGDyK) and BMP-2.ACS Appl Master Interfaces. doi: 10.1021/acsami.8b08900.
Stappert L, Klaus F, Brüstle O (2018) MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis. Frontiers in Neuroscience 12:707.
Spitzhorn LS, Kordes C, Megges M, Sawitza I, Götze S, Reichert D, Schulze-Matz P, Graffmann N, Bohndorf M, Wruck W, Köhler JP, Herebian D, Mayatepek E, Oreffo RO, Häussinger D, Adjaye J. (2018) Transplanted human pluripotent stem cell-derived mesenchymal stem cells support liver regeneration in Gunn rats. Stem Cells Dev. doi: 10.1089/scd.2018.0010.
Kutsche LK, Gysi DM, Fallmann J, Lenk K, Petri R, Swiersy A, Klapper SD, Pircs K, Khattak S, Stadler PF, Jakobsson J, Nowick K, Busskamp V (2018) Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. Cell Syst. Oct 24;7(4):438-452.e8.
Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch L, Eckert D, Hebisch M, Fischer J, Kesavan J, Weykopf B, Schneider L, Holtkamp D, Beck H, Till A, Wüllner U,Ziller MJ, Wagner W, Peitz M, Brüstle O (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nature Communications. 9:4047.
Abraham JA, Linnartz C, Dreissen G, Springer R, Blaschke S, Rueger MA, Fink GR, Hoffmann B, Merkel R (2018) Directing Neuronal Outgrowth and Network Formation of Rat Cortical Neurons by Cyclic Substrate Stretch. Langmuir. doi: 10.1021/acs.langmuir.8b02003.
Steens J, Klein D (2018) Current Strategies to generate Human Mesenchymal Stem Cells in vitro. Stem Cells Int. doi.org/10.1155/2018/6726185.
Klein D (2018) iPSCs-based generation of vascular cells: reprogramming approaches and applications. Cell Mol Life Sci. 75(8):1411-1433.
Kumar P, Efstathopoulos P, Millischer V, Olsson E, Bin Wei Y, Brüstle O, Schalling M, Villaescusa JC, Ösby U, Lavebratt C. (2018) Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment. Sci Rep. Aug 24;8(1):12743.
Troschel FM, Böhly N, Borrmann K, Braun T, Schwickert A, Kiesel L, Eich HT, Götte M, Greve B. (2018) miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro.Tumour Biol. Aug;40(8):1010428318791887.
Vay SU, Flitsch LJ, Rabenstein M, Rogall R, Blaschke S, Kleinhaus J, Reinert N, Bach A, Fink GR, Schroeter M, Rueger MA (2018) The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo. J Neuroinflammation. Aug 13;15(1):226.
Evert BO, Nalavade R, Jungverdorben J, Matthes F, Weber S, Rajput A, Bonn S, Brüstle O, Peitz M, Krauß S. (2018) Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3. PLoS One. Aug 7;13(8):e0201794.
Mirzaei R, Sarkar S, Dzikowski L, Rawji KS, Faissner A and Yong VW (2018) Brain tumor-initiating cells export tenascin-C in exosomes to suppress T cell Activity.Oncoimmunology. Aug 6;7(10):e1478647.
Witzler M, Alzagameem A, Bergs M, Khaldi-Hansen BE, Klein SE, Hielscher D, Kamm B, Kreyenschmidt J, Tobiasch E, Schulze M. (2018) Lignin-Derived Biomaterials for Drug Release and Tissue Engineering.Molecules. Jul 27;23(8). pii: E1885.
May M, Denecke B, Schroeder T, Götz M and Faissner A (2018) Cell tracking in vitro reveals that the extracellular matrix glycoprotein tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord.Biol Open. Jul 25;7(7). pii: bio027730.
Graffmann N, Ncube A, Wruck W, Adjaye J. (2018) Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density. PLoS One. Jul 10;13(7):e0200416.
Laganà AS, Salmeri FM, Vitale SG, Triolo O, Götte M. (2018) Stem Cell Trafficking During Endometriosis: May Epigenetics Play a Pivotal Role?Reprod Sci. Jul;25(7):978-979.
Abu-Dawud R, Graffmann N, Ferber S, Wruck W, Adjaye J. (2018) Pluripotent stem cells: induction and self-renewal.Philos Trans R Soc Lond B Biol Sci. Jul 5;373(1750).
Rogall R, Rabenstein M, Vay S, Bach A, Pikhovych A, Baermann J, Hoehn M, Couillard-Despres S, Fink GR, Schroeter M, Rueger MA (2018) Bioluminescence imaging visualizes osteopontin-induced neurogenesis and neuroblast migration in the mouse brain after stroke. Stem Cell Res Ther. Jul 4;9(1):182.
Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K. (2018) Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.Cell Stem Cell. Jul 4. pii: S1934-5909(18)30295-9.
Rabenstein M, Rueger MA (2018) Mobilization of Endogenous Neural Stem Cells to Promote Regeneration After Stroke. In: Lapchak P., Zhang J. (eds) Cellular and Molecular Approaches to Regeneration and Repair. Springer Series in Translational Stroke Research. Springer: 101-112.
Apel C, Buttler P, Salber J, Dhanasingh A, Neuss S. (2018) Differential mineralization of human dental pulp stem cells on different polymers.Biomed Tech (Berl). Jun 27;63(3):261-269.
Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E. (2018) Repurposing HAMI3379 to block GPR17 and promote rodent and human oligodendrocyte differentiation. Cell Chem Biol. Jun 21;25(6):775-786.e5.
Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustavsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A (2018) Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Front. Immunol. Jun 13; 9:1326.
Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, Araúzo-Bravo MJ, Boerno ST, Timmermann B, Vingron M, Schöler HR. (2018) Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency. Cell Stem Cell. Jun 11. pii: S1934-5909(18)30238-8.
Poppe D, Doerr J, Schneider M, Wilkens R, Steinbeck JA, Ladewig J, Tam A, Paschon DE, Gregory PD, Reik A, Müller CE, Koch P, Brüstle O. (2018) Genome editing in neuroepithelial stem cells to generate human neurons with high adenosine-releasing capacity. Stem Cells Transl Med. Jun;7(6):477-486.
Hielscher D, Kaebisch C, Braun BJV, Gray K, Tobiasch E. (2018) Stem Cell Sources and Graft Material for Vascular Tissue Engineering. Stem Cell Rev. Jun 2.
Martins S, Yigit H, Bohndorf M, Graffmann N, Fiszl AR, Wruck W, Sleegers K, Van Broeckhoven C, Adjaye J. (2018) Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Stem Cell Res. Jun 1;30:141-144.
Peitz M, Bechler T, Thiele CC, Veltel M, Bloschies M, Fliessbach K, Ramirez A, Brüstle O. (2018) Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ?4/?4 genotype. Stem Cell Res. May;29:250-253.
Frobel J, Rahmig S, Franzen J, Waskow C, Wagner W. (2018) Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice.Clin Epigenetics. May 22; 10: 67.
Allison TF, Andrews PW, Avior Y, Barbaric I, Benvenisty N, Bock C, Brehm J, Brüstle O, Damjanov I, Elefanty A, Felkner D, Gokhale PJ, Halbritter F, Healy LE, Hu TX, Knowles BB, Loring JF, Ludwig TE, Mayberry R, Micallef S, Mohamed JS, Müller FJ, Mummery CL, Nakatsuji N, Ng ES, Oh SKW, O'Shea O, Pera MF, Reubinoff B, Robson P, Rossant J, Schuldt BM, Solter D, Sourris K, Stacey G, Stanley EG, Suemori H, Takahashi K, Yamanaka S. (2018) Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nat Commun. May 15;9(1):1925.
Lindemann M, Eiz-Vesper B, Steckel NK, Tischer S, Fiedler M, Heinold A, Klisanin V, Maecker-Kolhoff B, Blasczyk R, Horn PA, Beelen DW, Koldehoff M (2018) Adoptive transfer of cellular immunity against cytomegalovirus by virus-specific lymphocytes from a third party family donor. Bone Marrow Transplant. May 8. doi: 10.1038/s41409-018-0209-2.
Goetzke R, Sechi A, de Laporte L, Neuss-Stein S, Wagner W. (2018) Why the impact of mechanical stimuli on stem cells remains a challenge. Cell Mol Life Sci., May 4, pp 1–16.
Kreß H (2018), Xenotransplantation in ethischer, kultureller und religionsbezogener Hinsicht. In: Sautermeister J (ed.), Tierische Organe in menschlichen Körpern, mentis, Paderborn, 2018, S. 333–350
Jostes S, Schorle H. (2018) Signals and transcription factors for specification of human germ cells.Stem Cell Investig. Apr 29;5:13.
Rahman MS, Spitzhorn LS, Wruck W, Hagenbeck C, Balan P, Graffmann N, Bohndorf M, Ncube A, Guillot PV, Fehm T, Adjaye J. (2018) The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time.Stem Cell Res Ther. Apr 25;9(1):113.
Azim K, Akkermann R, Cantone M, Vera J, Jadasz JJ, Küry P. (2018) Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.Front Neurosci. Apr 20;12:220.
Kordelas L, da Silva Nardi F, Wagener B, Ditschkowski M, Liebregts T, Lindemann M, Heinemann FM, Horn PA, Beelen DW, Rebmann V (2018) Elevated soluble human leukocyte antigen G levels in patients after allogeneic stem cell transplantation are associated with less severe acute and chronic graft-versus-host disease. Bone Marrow Transplant. Mar 14; doi: 10.1038/s41409-018-0145-1.
Wruck W, Adjaye J.(2018) Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis.Sci Data. Mar 13;5:180035.
Teichweyde N, Kasperidus L, Carotta S, Kouskoff V, Lacaud G, Horn PA, Heinrichs S and Klump H. (2018) HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development.Stem Cell Reports. Mar 13;10(3):875-889.
Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T. (2018) Expansion of functional personalized cells with specific transgene combinations. Nat Commun. Mar 8;9(1):994.
Weider M, Starost LJ, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M. (2018) Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.Nat Commun. Mar 2;9(1):899
Schüring AN, Dahlhues B, Korte A, Kiesel L, Titze U, Heitkötter B, Ruckert C, Götte M. (2018) The endometrial stem cell markers notch-1 and numb are associated with endometriosis.Reprod Biomed Online. Mar;36(3):294-301.
FrobelJ, Bozic T, Lenz M, Uciechowski P, Han Y, Herwartz R, Strathmann K, Isfort S, Panse J, Esser A, Birkhofer C, Gerstenmaier U, Kraus T, Rink L, Koschmieder S, Wagner W. (2018) Leukocyte counts based on DNA methylation at individual cytosines. Clin Chem. Mar;64(3):566-575.
Jungverdorben J, Till A, Brüstle O. (2018) Modellierung neurodegenerativer Erkrankungen mittels induziert pluripotenter Stammzellen (iPS-Zellen): ein Fokus auf Autophagie. In: Stammzellforschung - Aktuelle wissenschaftliche und gesellschaftliche Entwicklungen (Eds.: Zenke M, Marx-Stölting, L., Schickl, H.), Forschungsberichte der Interdisziplinären Arbeitsgruppen der Berlin-Brandenburgischen Akademie der Wissenschaften, Nomos, Kapitel 3.2.
Carra S, Sangiorgio L, Pelucchi P, Cermenati S, Mezzelani A, Martino V, Palizban M, Albertini A, Götte M, Kehler J, Deflorian G, Beltrame M, Giordano A, Reinbold R, Cotelli F, Bellipanni G, Zucchi I. (2018) Zebrafish Tmem230a cooperates with the Delta/Notch signaling pathway to modulate endothelial cell number in angiogenic vessels.J Cell Physiol. Feb;233(2):1455-1467.
Goetzke R, Franzen J, Ostrowska A, Vogt M, Blaeser A, Klein G, Rath B, Fischer H, Zenke M, Wagner W. (2018) Does Soft Really Matter? Differentiation of Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells is Not Influenced by Soft Hydrogels. Biomaterials, Feb;156:147-158.
Franzen J, Zirkel A, Blake J, Rath B, Benes V, Papantonis A, Wagner W.(2018) Senescence-Associated DNA Methylation is Stochastically Acquired in Subpopulations of Mesenchymal Stem Cells. Aging Cell, Feb;16(1):183-191.
Pachernegg S, Eilebrecht S, Eilebrecht E, Schöneborn H, Neumann S, Benecke AG, Hollmann M. (2018) The siRNA-mediated knockdown of GluN3A in 46C-derived neural stem cells affects mRNA expression levels of neural genes, including known iGluR interactors.PLoS One. Feb 13;13(2):e0192242.
Ventura Ferreira MS, Bienert M, Müller K, Rath B, Goecke T, Opländer C, Braunschweig T, Mela P, Brümmendorf TH, Beier F, Neuss S. (2018) Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.Stem Cell Res Ther, Feb 5;9(1):28.
de Boni L, Gasparoni G, Haubenreich C, Tierling S, Schmitt I, Peitz M, Koch P, Walter J, Wüllner U, Brüstle O. (2018) DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling. Clin Epigenetics. Jan 29;10:13.
Koldehoff M, Lindemann M, Ross SR, Elmaagacli AH (2018) Cytomegalovirus induces HLA-class-II-restricted alloreactivity in an acute myeloid leukemia cell line. PLoS One. Jan 29;13(1):e0191482.
Münst S, Koch P, Kesavan J, Alexander-Mays M, Münst B, Blaess S, Brüstle O. (2018) In vitro segregation and isolation of human pluripotent stem cell-derived neural crest cells. Methods. Jan 15;133:65-80.
Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. (2018) Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.Glia. Jan;66(1):145-160.
Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C (2018) Growth factor independence 1b. A key player in the genesis and maintenance of acute myeloid leukaemia and myelodysplastic syndrome.Haematologica. Jan 11; 103(4):614-25.
Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulus KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Liebermann S, Kreines F, Shono F, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA (2018) Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. Nature Medicine. Jan 08; 24(2):239-46.
Berke S, Kampmann AL, Wuest M, Bailey JJ, Glowacki B, Wuest F, Jurkschat K, Weberskirch R, Schirrmacher R (2018) 18F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core-Shell Nanoparticles.Bioconjug Chem.Jan 17;29(1):89-95.
Rolfes V, Bittner U, Fangerau H (2018): Die bioethische Debatte um die Stammzellforschung: induzierte pluripotente Stammzellen zwischen Lösung und Problem? In: Zenke M, Marx-Stölting L, Schickl H (eds): Stammzellforschung: Aktuelle wissenschaftliche und gesellschaftliche Entwicklungen. Nomos, Baden-Baden, S. 153-178, erschienen Januar 2018.

2017

Giebel B, Kordelas L, Börger V (2017). Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles. Stem Cell Investig 4, 84.
Giebel B (2017). On the function and heterogeneity of extracellular vesicles. Ann Transl Med 5, 150.
Börger V, Bremer M, Ferrer-Tur R, Gockeln L, Stambouli O, Becic A, Giebel B (2017). Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents.Int J Mol Sci 18(7): 1450.
Rolfes V, Gerhards H, Opper J, Bittner U, Roth PH, Fangerau H, Gassner UM, Martinsen R (2017). Diskurse über induzierte pluripotente Stammzellforschung und ihre Auswirkungen auf die Gestaltung sozialkompatibler Lösungen – eine interdisziplinäre Bestandsaufnahme. Jahrbuch für Wissenschaft und Ethik 22:65-86.
Kubaczka C, Kaiser F, Schorle H. (2017) Breaking the first lineage barrier - many roads to trophoblast stem cell fate.Placenta. Dec;60 Suppl 1:S52-S56.
Leiendecker A, Schulze M, Tobiasch E, Witzleben S. (2017) Template-mediated Biomineralization for Bone Tissue Engineering. Special issue: Nanobiomaterials for improving stem cell applications in tissue engineering and regenerative medicine.Curr Stem Cell Res Ther. 12(2):103-123.
Pfützner A, Schipper D, Pansky A, Kleinfeld C, Roitzheim B, Tobiasch E. (2017) Mesenchymal Stem Cell Differentiation into Adipocytes Is Equally Induced by Insulin and Proinsulin In Vitro.Int J Stem Cells. Nov 30;10(2):154-159.
Klein D, Steens J, Wiesemann A, Schulz FC, Kaschani F, Roeck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer J, Stuschke M, Jendrossek V (2017) Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression. Antioxid Redox Signal. 26(11):563-582.
Steens J, Zuk M, Benchellal M, Bornemann L, Teichweyde N, Hess J, Unger K, Görgens A, Klump H, Klein D (2017) In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells. Stem Cell Reports. 8(4): 919–932.
Ju Lee H, Bartsch D, Xiao C, Guerrero S, Ahuja G, Schindler C, Moresco JJ, Yates JR 3rd, Gebauer F, Bazzi H, Dieterich C, Kurian L, Vilchez D (2017) A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nat Commun. Nov 13;8(1):1456.
van de Kamp J, Paefgen V, Wöltje M, Böbel M, Jaekel J, Rath B, Labude N, Knüchel R, Jahnen-Dechent W, Neuss S. (2017) Mesenchymal stem cells can be recruited to wounded tissue via hepatocyte growth factor-loaded biomaterials.J Tissue Eng Regen Med. Nov;11(11):2988-2998.
Klapper SD, Sauter EJ, Swiersy A, Hyman MAE, Bamann C, Bamberg E, Busskamp V (2017) On-demand optogenetic activation of human stem-cell-derived neurons. Sci Rep. Oct 31;7(1):14450.
Reinhard J, Roll L and Faissner A (2017) Tenascins in retinal and optic nerve neurodegeneration.Front Integr Neurosci. Oct 23;11:30.
Petri RM, Hackel A, Hahnel K, Dumitru CA, Bruderek K, Flohe SB, Paschen A, Lang S, Brandau S. (2017) Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.Stem Cell Reports. Sep 12;9(3):985-998.
Antal A, Alekseichuk I, Bikson M, Brockmöller J, Brunoni AR, Chen R, Cohen LG, Dowthwaite G, Ellrich J, Flöel A, Fregni F, George MS, Hamilton R, Haueisen J, Herrmann CS, Hummel FC, Lefaucheur JP, Liebetanz D, Loo CK, McCaig CD, Miniussi C, Miranda PC, Moliadze V, Nitsche MA, Nowak R, Padberg F, Pascual-Leone A, Poppendieck W, Priori A, Rossi S, Rossini PM, Rothwell J, Rueger MA, Ruffini G, Schellhorn K, Siebner HR, Ugawa Y, Wexler A, Ziemann U, Hallett M, Paulus W (2017). Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines. Clin Neurophysiol; 128(9): 1774-1809.
König L, Kasimir-Bauer S, Bittner AK, Hoffmann O, Wagner B, Manveiler LFS, Kimmig R, Horn PA, Rebmann V (2017) Elevated levels of extracellular vesicles are associated with therapy failure and disease progression in breast cancer patients undergoing neoadjuvant chemotherapy. OncoImmunology. 7:1, e1376153.
Abagnale G, Sechi A, Steger M, Zhou Y, Kuo CC, Aydin G, Schalla C, Müller-Newen G, Zenke M, Costa IG, van Rijn P, Gillner A, Wagner W. (2017) Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies. Stem Cell Reports, Aug 8; 9(2): 654–666.
Koch, P., Ladewig, J. (2017) A little bit of guidance: Mini brains on their route to adolescence. Cell Stem Cell. Aug 3;21(2):157-158.
Jungverdorben J, Till A, Brüstle O. (2017) Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. J Mol Med (Berl). Jul;95(7):705-718.
Wagner W. (2017) Epigenetic aging clocks in mice and men. Genome Biol, Jun 14;18(1):107.
Faissner A, Roll L, and Theocharidis U (2017) Tenascin-C in the matrisome of neural stem and progenitor cells.Mol Cell Neurosci Jun;81:22-31.
Kehler J, Greco M, Martino V, Pachiappan M, Yokoe H, Chen A, Yang M, Auerbach J, Jessee J, Götte M, Milanesi L, Albertini A, Bellipanni G, Zucchi I, Reinbold RA, Giordano A.(2017) RNA-Generated and Gene-Edited Induced Pluripotent Stem Cells for Disease Modeling and Therapy.J Cell Physiol. Jun;232(6):1262-1269.
Schuler PJ, Brandau S. (2017) Adenosine Producing Mesenchymal Stem Cells. Stem Cells. Jun;35(6):1647-1648.
Kandasamy M, Roll L, Langenstroth D, Brüstle O, Faissner A. (2017) Glycoconjugates reveal diversity of human neural stem cells (hNSCs) derived from human induced pluripotent stem cells (hiPSCs). Cell Tissue Res. Jun;368(3):531-549.
Siegel G, Gerber H, Koch P, Brüstle O, Fraering PC, Rajendran L. (2017) The Alzheimer's disease y-secretase generates higher 42:40 ratios for ß-amyloid than for p3 peptides. Cell Rep. Jun 6;19(10):1967-1976.
Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R. (2017) Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. Brain. Jun 1;140(6):1561-1578.
Ulc A, Gottschling C, Schäfer I, Wegrzyn D, van Leeuwen S, Luft V, Reinhard J and Faissner A (2017) Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system plasticity.Biol Chem. May 1;398(5-6):663-675.
Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS.(2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.Matrix Biol. May;59:3-22.
Roese-Koerner B, Stappert L, Brüstle O. (2017) Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Neurogenesis. May 12;4(1):e1313647.
De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brüstle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolén G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE.. (2017) Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.Stem Cell Res. Apr;20:105-114.
Gabriel E, Gopalakrishnan J (2017) Generation of iPSC-derived human brain organoids to model early neurodevelopmental disorders. J Vis Exp. Apr 14;(122).
Iefremova V, Manikakis G, Krefft O, Jabali A, Weynans K, Wilkens R, Marsoner F, Brändl B, Müller FJ, Koch P, Ladewig J (2017) An organoid-based model of cortical development identifies non-cell-autonomous defects in Wnt signaling contributing to Miller-Dieker Syndrome. Cell Reports. Apr;19 (1):50–59.
Akkermann R, Beyer F, Küry P. (2017) Heterogeneous populations of neural stem cells contribute to myelin repair.Neural Regen Res. Apr;12(4):509-517.
Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K. (2017) Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies.Stem Cells. Apr;35(4):859-871.
Schipper D, Babczyk P, El-Sayed F, Klein SE, Schulze M, Tobiasch E. (2017) The Effect of Nanostructured Surfaces on Stem Cell Fate. In “Nanostructures for Novel Therapy”. Editors: A. M. Grumezescu, D. Ficai. Elsevier.
Hansen B, El-Sayed F, Tobiasch E, Witzleben S, Schulze M. (2017) Functionalized 3D Scaffolds for Template-Mediated Biomineralization in Bone Regeneration. In “Frontiers in Stem Cell and Regenerative Medicine Research”. Editors: Atta-ur-Rahman and Shazia Anjum. Bentham Science Publishers. Vol. 5, 130-178.
Sallouh M, Jarocki M, Sallouh O, Degen P, Faissner A and Weberskirch R (2017) The Synergistic Effect of Cationic Moieties and GRGDSF-Peptides in Hydrogels on Neural Stem Cell Behavior.Macromol Biosci. Mar;17(3).
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. (2017) Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proc Natl Acad Sci U S A. Mar 14;114(11):E2243-E2252
Ibrahim SA, Gadalla R, El-Ghonaimy EA, Samir O, Mohamed HT, Hassan H, Greve B, El-Shinawi M, Mohamed MM, Götte M. (2017) Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways.Mol Cancer. Mar 7;16(1):57.
Reinhard J, Renner M, Wiemann S, Shakoor DA, Stute G, Dick HB, Faissner A and Joachim SC (2017) Ischemic injury leads to extracellular matrix alterations in retina and optic nerve.Sci Rep. Mar 6; 7:43470.
Hallmann AL, Araúzo-Bravo MJ, Mavrommatis L, Ehrlich M, Röpke A, Brockhaus J, Missler M, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H, Hargus G. (2017) Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Sci Rep. Mar 3;7:42991.
Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen O, Gopalakrishnan J. (2017) Recent Zika virus isolates induce premature differentiation of neural progenitors in human brain organoids.Cell Stem Cell Mar 2;20(3):397-406.e5.
Tornero D, Tsupykov O, Granmo M, Rodriguez C, Grønning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brüstle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z. (2017) Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli. Brain. Mar 1;140(3):692-706.
Badenes SM, Fernandes TG, Miranda CC, Pusch-Klein A, Haupt S, Rodrigues CAV, Diogoa MM, Brüstle O, Cabrala JMS (2017) Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. J Chem Technol Biotechnol. 92(3):492-503.
Kather M, Skischus M, Kandt P, Pich A, Conrads G, Neuss S. (2017) Functional isoeugenol-modified nanogel coatings for design of biointerfaces.Angew Chem Int Ed, Feb 20;56(9):2497-2502.
Demuth HU, Dijkhuizen RM, Farr TD, Gelderblom M, Horsburgh K, Iadecola C, Mcleod D, Michalski D, Murphy TH, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Saur D, Savitz SI, Schilling S, Spratt NJ, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M, Boltze J (2017) Recent progress in translational research on neurovascular and neurodegenerative disorders. Restor Neurol Neurosci; 35(1): 87-103.
Pelusi N, Kosanke M, Riedt T, Rösseler C, Seré K, Li J, Gütgemann I, Zenke M, Janzen V, Schorle H. (2017) The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm.Sci Rep. Jan 27;7:41427.
Doerr J, Schwarz MK, Wiedermann D, Leinhaas A, Jakobs A, Schloen F, Schwarz I, Diedenhofen M, Braun NC, Koch P, Peterson DA, Kubitscheck U, Hoehn M, Brüstle O. (2017) Whole-brain 3D mapping of human neural transplant innervation. Nat Commun. Jan 19;8:14162.
Lam RS, Töpfer FM, Wood PG, Busskamp V, Bamberg E (2017) Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures. PLoS One. Jan 4;12(1):e0169506.
Reinartz R, Wang S, Kebir S, Silver DJ, Wieland A, Zheng T, Küpper M, Rauschenbach L, Fimmers R, Shepherd TM, Trageser D, Till A, Schäfer N, Glas M, Hillmer AM, Cichon S, Smith AA, Pietsch T, Liu Y, Reynolds BA, Yachnis A, Pincus DW, Simon M, Brüstle O, Steindler DA, Scheffler B. (2017) Functional subclone profiling for prediction of treatment-induced intra-tumor population shifts and discovery of rational drug combinations in human glioblastoma. Clin Cancer Res. Jan 15;23(2):562-574.

Research

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