Publications

Publications since 2017 of research groups participating in the network are listed below.

2020

Rahman S, Wruck W, Spitzhorn LS, Nguyen L, Bohndorf M, Martins S, Asar F, Ncube A, Erichsen L, Graffmann N , Adjaye J (2020): The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor Cells. Scientific Reports. 10, 739.

2019

Kniebs C, Kreimendahl F, Köpf M, Fischer H, Jockenhoevel S, Thiebes AL (2019): Influence of Different Cell Types and Sources on Pre-Vascularisation in Fibrin and Agarose–Collagen Gels. Organogenesis. Dec 6:1-13, doi: 10.1080/15476278.2019.1697597.
Steens J, Unger K, Klar L, Neureiter A, Wieber K, Hess J, Jakob HG, Klump H, Klein D (2019) Direct conversion of human fibroblasts into therapeutically active vascular wall‑typical mesenchymal stem cells. Cellular and Molecular Life Sciences. Nov 11,doi: 10.1007/s00018-019-03358-0.
Han Y, Franzen J, Stiehl T, Gobs M, Kuo C, Nikolić M, Hapala J, Elisabeth Koop B, Strathmann K, Ritz‐Timme S, Wagner W (2019) New Targeted Approaches for Epigenetic Age Predictions. bioRxiv. doi: 10.1101/799031.
Radtke S, Görgens A, da Conceição Castro SV, Kordelas L, Köninger A, Dürig J, Möllmann M, Horn PA, Giebel B (2019) Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice. Scientific Reports. Sep 9;9(1):12914.
Kordelas L, Görgens A, Radtke S, Horn PA, Beelen DW, Giebel B (2019) Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows. Bone Marrow Transplantation. doi: 10.1038/s41409-019-0645-7.
Ostermann L, Ladewig J, Müller FJ, Kesevan J, Tailor J, Smith A, Brüstle O, Koch P (2019) In vitro recapitulation of developmental transitions in human neural stem cells. Stem Cells. Jul 24. doi: 10.1002/stem.3065.
Rehbach K, Kesavan J, Hauser S, Ritzenhofen S, Jungverdorben J, Schüle R, Schöls L, Peitz M, Brüstle O (2019) Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. Scientific Reports. Jul 9: 9615.
Vitale D, Kumar Katakam S, Greve B, Jang B, Oh ES, Alaniz L, Götte M (2019) Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance. FEBS Journal. Jun 23. doi: 10.1111/febs.14967.
Roth PH, Gerhards H (2019) Es ist nicht alles Gold, was glänzt… Die politische Rhetorik des ‚Goldstandards‘ und die diskursive Legitimierung der humanen embryonalen Stammzellforschung in Deutschland. In: Zeitschrift für Politik 66 (2): 143-164.
Blaschke S, Vay SU, Pallast N, Rabenstein M, Abraham JA, Linnartz C, Hoffmann M, Hersch N, Merkel R, Hoffmann B, Fink GR, Rueger MA (2019). Substrate elasticity induces quiescence and promotes neurogenesis of primary neural stem cells - a biophysical in vitro model of the physiological cerebral milieu. J Tissue Eng Regen Med. Jun 13 (6):960-972.
Meents JE, Bressan E, Sontag S, Foerster A, Hautvast P, Rösseler C, Hampl M, Schüler H, Goetzke R, Le TKC, Kleggetveit IP, Le Cann K, Kerth C, Rush AM, Rogers M, Kohl Z, Schmelz M, Wagner W, Jørum E, Namer B, Winner B, Zenke M, Lampert A (2019) The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Pain. Jun 160 (6):1327-1341.
Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, Peitz M, Toonen RF, Brüstle O, Verhage M (2019) A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons. Cell Reports 27 (7): 2199-2211.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, Brose N, Brüstle O, Rhee JS (2019) An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons. Cell Reports. 27 (7): 2212-2228.
Spitzhorn LS, Megges M, Wruck W, Rahman MS, Otte J, Degistirici Ö, Meisel R, Sorg RV, Oreffo ROC, Adjaye J (2019) Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature. Stem Cell Research & Therapy. 10(1):100.
Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling J, Dodzian J, Lagerborg KA, Vargas N, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano D, Kurian L (2019) Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Reports. Apr 20 (4).
Kuo CC, Hänzelmann S, Sentürk Cetin N, Frank S, Zajzon B, Derks JP, Akhade VS, Ahuja G, Kanduri C, Grummt I, Kurian L, Costa IG (2019) Detection of RNA-DNA binding sites in long noncoding RNAs. Nucleic Acids Res. Apr 8;47(6):e32.
Kordelas L, Schwich E, Dittrich R, Horn PA, Beelen DW, Börger V, Giebel B, Rebmann V (2019) Individual Immune-Modulatory Capabilities of MSC-Derived Extracellular Vesicle (EV) Preparations and Recipient-Dependent Responsiveness. International Journal of Molecular Sciences. Apr 2;20(7). pii: e1642.
Sauter EJ, Kutsche LK, Klapper SD, Busskamp V (2019) Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders. Methods Mol Biol. 1942:101-121.
Vaswani AR, Weykopf B, Hagemann C, Fried HU, Brüstle O, Blaess S (2019) Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons.Elife. Jan 28;8. pii: e41623.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2019) yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell. Feb 7;24(2):318-327.e8.
Weykopf B , Haupt S , Jungverdorben J , Flitsch LJ., Hebisch M , Liu G , Suzuki K , Belmonte, JC., Peitz M , Blaess, S , Till, A, Brüstle, O (2019) Induced pluripotent stem cell‐based modeling of mutant LRRK2‐associated Parkinson's Disease. European Journal of Neuroscience. Jan 49 (4): 561– 589.
Jarocki M, Sallouh O, Weberskirch R, Faissner A. (2019) The Tenascin-C-Derived Peptide VSWRAPTA Promotes Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro.Mol Neurobiol. Jan;56(1):632-647.

2018

Namer B, Schmidt D, Eberhardt E, Maroni M, Dorfmeister E, Kleggetveit IP, Kaluza L, Meents J, Gerlach A, Lin Z, Winterpacht A, Dragicevic E, Kohl Z, Schüttler J, Kurth I, Warncke T, Jorum E, Winner B, Lampert A. (2018) Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors.EBioMedicine. Nov 28. pii: S2352-3964(18)30546-2.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L (2018) yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs, Cell Stem Cell, Nov 21. pii: S1934-5909(18)30541-1.
Gerhards H und Martinsen R (2018) Vom ethischen Frame zum Risikodispositiv: Der gewandelte Diskurs zur Stammzellforschung und ihren Anwendungen, in: Martinsen R und Niederberger A (2018) Risikoforschung, UNIKATE, Ausgabe 52, 68-81.
Niemietz C, Fleischhauer L, Sandfort V, Guttmann S, Zibert A, Schmidt HH (2018) Hepatocyte-like cells reveal novel role of SERPINA1 in transthyretin amyloidosis.J Cell Sci. Nov 26;131(23). pii: jcs219824.
Böke F, Labude N, Lauria I, Ernst S, Müller-Newen G, Neuss S, Fischer H (2018) Biological Activation of Bioinert Medical High Performance Oxide Ceramics by Hydrolytically Stable Immobilization of c(RGDyK) and BMP-2.ACS Appl Master Interfaces. doi: 10.1021/acsami.8b08900.
Stappert L, Klaus F, Brüstle O (2018) MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis. Frontiers in Neuroscience 12:707.
Spitzhorn LS, Kordes C, Megges M, Sawitza I, Götze S, Reichert D, Schulze-Matz P, Graffmann N, Bohndorf M, Wruck W, Köhler JP, Herebian D, Mayatepek E, Oreffo RO, Häussinger D, Adjaye J. (2018) Transplanted human pluripotent stem cell-derived mesenchymal stem cells support liver regeneration in Gunn rats. Stem Cells Dev. doi: 10.1089/scd.2018.0010.
Kutsche LK, Gysi DM, Fallmann J, Lenk K, Petri R, Swiersy A, Klapper SD, Pircs K, Khattak S, Stadler PF, Jakobsson J, Nowick K, Busskamp V (2018) Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis.Cell Syst. Oct 24;7(4):438-452.e8.
Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch L, Eckert D, Hebisch M, Fischer J, Kesavan J, Weykopf B, Schneider L, Holtkamp D, Beck H, Till A, Wüllner U,Ziller MJ, Wagner W, Peitz M, Brüstle O (2018)A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nature Communications. 9:4047.
Abraham JA, Linnartz C, Dreissen G, Springer R, Blaschke S, Rueger MA, Fink GR, Hoffmann B, Merkel R (2018) Directing Neuronal Outgrowth and Network Formation of Rat Cortical Neurons by Cyclic Substrate Stretch. Langmuir. doi: 10.1021/acs.langmuir.8b02003.
Steens J, Klein D (2018) Current Strategies to generate Human Mesenchymal Stem Cells in vitro. Stem Cells Int. doi.org/10.1155/2018/6726185.
Klein D (2018) iPSCs-based generation of vascular cells: reprogramming approaches and applications. Cell Mol Life Sci. 75(8):1411-1433.
Kumar P, Efstathopoulos P, Millischer V, Olsson E, Bin Wei Y, Brüstle O, Schalling M, Villaescusa JC, Ösby U, Lavebratt C. (2018) Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment. Sci Rep. Aug 24;8(1):12743.
Troschel FM, Böhly N, Borrmann K, Braun T, Schwickert A, Kiesel L, Eich HT, Götte M, Greve B. (2018) miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro.Tumour Biol. Aug;40(8):1010428318791887.
Vay SU, Flitsch LJ, Rabenstein M, Rogall R, Blaschke S, Kleinhaus J, Reinert N, Bach A, Fink GR, Schroeter M, Rueger MA (2018) The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo. J Neuroinflammation. Aug 13;15(1):226.
Evert BO, Nalavade R, Jungverdorben J, Matthes F, Weber S, Rajput A, Bonn S, Brüstle O, Peitz M, Krauß S. (2018) Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3. PLoS One. Aug 7;13(8):e0201794.
Mirzaei R, Sarkar S, Dzikowski L, Rawji KS, Faissner A and Yong VW (2018) Brain tumor-initiating cells export tenascin-C in exosomes to suppress T cell Activity.Oncoimmunology. Aug 6;7(10):e1478647.
Witzler M, Alzagameem A, Bergs M, Khaldi-Hansen BE, Klein SE, Hielscher D, Kamm B, Kreyenschmidt J, Tobiasch E, Schulze M. (2018) Lignin-Derived Biomaterials for Drug Release and Tissue Engineering.Molecules. Jul 27;23(8). pii: E1885.
May M, Denecke B, Schroeder T, Götz M and Faissner A (2018) Cell tracking in vitro reveals that the extracellular matrix glycoprotein tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord.Biol Open. Jul 25;7(7). pii: bio027730.
Graffmann N, Ncube A, Wruck W, Adjaye J. (2018) Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density. PLoS One. Jul 10;13(7):e0200416.
Laganà AS, Salmeri FM, Vitale SG, Triolo O, Götte M. (2018) Stem Cell Trafficking During Endometriosis: May Epigenetics Play a Pivotal Role?Reprod Sci. Jul;25(7):978-979.
Abu-Dawud R, Graffmann N, Ferber S, Wruck W, Adjaye J. (2018) Pluripotent stem cells: induction and self-renewal.Philos Trans R Soc Lond B Biol Sci. Jul 5;373(1750).
Rogall R, Rabenstein M, Vay S, Bach A, Pikhovych A, Baermann J, Hoehn M, Couillard-Despres S, Fink GR, Schroeter M, Rueger MA (2018) Bioluminescence imaging visualizes osteopontin-induced neurogenesis and neuroblast migration in the mouse brain after stroke. Stem Cell Res Ther. Jul 4;9(1):182.
Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K. (2018) Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.Cell Stem Cell. Jul 4. pii: S1934-5909(18)30295-9.
Rabenstein M, Rueger MA (2018) Mobilization of Endogenous Neural Stem Cells to Promote Regeneration After Stroke. In: Lapchak P., Zhang J. (eds) Cellular and Molecular Approaches to Regeneration and Repair. Springer Series in Translational Stroke Research. Springer: 101-112.
Apel C, Buttler P, Salber J, Dhanasingh A, Neuss S. (2018) Differential mineralization of human dental pulp stem cells on different polymers.Biomed Tech (Berl). Jun 27;63(3):261-269.
Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E. (2018) Repurposing HAMI3379 to block GPR17 and promote rodent and human oligodendrocyte differentiation. Cell Chem Biol. Jun 21;25(6):775-786.e5.
Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustavsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A (2018) Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Front. Immunol. Jun 13; 9:1326.
Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, Araúzo-Bravo MJ, Boerno ST, Timmermann B, Vingron M, Schöler HR. (2018) Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency. Cell Stem Cell. Jun 11. pii: S1934-5909(18)30238-8.
Poppe D, Doerr J, Schneider M, Wilkens R, Steinbeck JA, Ladewig J, Tam A, Paschon DE, Gregory PD, Reik A, Müller CE, Koch P, Brüstle O. (2018) Genome editing in neuroepithelial stem cells to generate human neurons with high adenosine-releasing capacity. Stem Cells Transl Med. Jun;7(6):477-486.
Hielscher D, Kaebisch C, Braun BJV, Gray K, Tobiasch E. (2018) Stem Cell Sources and Graft Material for Vascular Tissue Engineering. Stem Cell Rev. Jun 2.
Martins S, Yigit H, Bohndorf M, Graffmann N, Fiszl AR, Wruck W, Sleegers K, Van Broeckhoven C, Adjaye J. (2018) Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Stem Cell Res. Jun 1;30:141-144.
Peitz M, Bechler T, Thiele CC, Veltel M, Bloschies M, Fliessbach K, Ramirez A, Brüstle O. (2018) Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ?4/?4 genotype. Stem Cell Res. May;29:250-253.
Frobel J, Rahmig S, Franzen J, Waskow C, Wagner W. (2018) Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice.Clin Epigenetics. May 22; 10: 67.
Allison TF, Andrews PW, Avior Y, Barbaric I, Benvenisty N, Bock C, Brehm J, Brüstle O, Damjanov I, Elefanty A, Felkner D, Gokhale PJ, Halbritter F, Healy LE, Hu TX, Knowles BB, Loring JF, Ludwig TE, Mayberry R, Micallef S, Mohamed JS, Müller FJ, Mummery CL, Nakatsuji N, Ng ES, Oh SKW, O'Shea O, Pera MF, Reubinoff B, Robson P, Rossant J, Schuldt BM, Solter D, Sourris K, Stacey G, Stanley EG, Suemori H, Takahashi K, Yamanaka S. (2018) Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nat Commun. May 15;9(1):1925.
Lindemann M, Eiz-Vesper B, Steckel NK, Tischer S, Fiedler M, Heinold A, Klisanin V, Maecker-Kolhoff B, Blasczyk R, Horn PA, Beelen DW, Koldehoff M (2018) Adoptive transfer of cellular immunity against cytomegalovirus by virus-specific lymphocytes from a third party family donor. Bone Marrow Transplant. May 8. doi: 10.1038/s41409-018-0209-2.
Goetzke R, Sechi A, de Laporte L, Neuss-Stein S, Wagner W. (2018) Why the impact of mechanical stimuli on stem cells remains a challenge. Cell Mol Life Sci., May 4, pp 1–16.
Kreß H (2018), Xenotransplantation in ethischer, kultureller und religionsbezogener Hinsicht. In: Sautermeister J (ed.), Tierische Organe in menschlichen Körpern, mentis, Paderborn, 2018, S. 333–350
Jostes S, Schorle H. (2018) Signals and transcription factors for specification of human germ cells.Stem Cell Investig. Apr 29;5:13.
Rahman MS, Spitzhorn LS, Wruck W, Hagenbeck C, Balan P, Graffmann N, Bohndorf M, Ncube A, Guillot PV, Fehm T, Adjaye J. (2018) The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time.Stem Cell Res Ther. Apr 25;9(1):113.
Azim K, Akkermann R, Cantone M, Vera J, Jadasz JJ, Küry P. (2018) Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.Front Neurosci. Apr 20;12:220.
Kordelas L, da Silva Nardi F, Wagener B, Ditschkowski M, Liebregts T, Lindemann M, Heinemann FM, Horn PA, Beelen DW, Rebmann V (2018) Elevated soluble human leukocyte antigen G levels in patients after allogeneic stem cell transplantation are associated with less severe acute and chronic graft-versus-host disease. Bone Marrow Transplant. Mar 14; doi: 10.1038/s41409-018-0145-1.
Wruck W, Adjaye J.(2018) Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis.Sci Data. Mar 13;5:180035.
Teichweyde N, Kasperidus L, Carotta S, Kouskoff V, Lacaud G, Horn PA, Heinrichs S and Klump H. (2018) HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development.Stem Cell Reports. Mar 13;10(3):875-889.
Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T. (2018) Expansion of functional personalized cells with specific transgene combinations. Nat Commun. Mar 8;9(1):994.
Weider M, Starost LJ, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M. (2018) Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.Nat Commun. Mar 2;9(1):899
Schüring AN, Dahlhues B, Korte A, Kiesel L, Titze U, Heitkötter B, Ruckert C, Götte M. (2018) The endometrial stem cell markers notch-1 and numb are associated with endometriosis.Reprod Biomed Online. Mar;36(3):294-301.
FrobelJ, Bozic T, Lenz M, Uciechowski P, Han Y, Herwartz R, Strathmann K, Isfort S, Panse J, Esser A, Birkhofer C, Gerstenmaier U, Kraus T, Rink L, Koschmieder S, Wagner W. (2018) Leukocyte counts based on DNA methylation at individual cytosines. Clin Chem. Mar;64(3):566-575.
Jungverdorben J, Till A, Brüstle O. (2018) Modellierung neurodegenerativer Erkrankungen mittels induziert pluripotenter Stammzellen (iPS-Zellen): ein Fokus auf Autophagie. In: Stammzellforschung - Aktuelle wissenschaftliche und gesellschaftliche Entwicklungen (Eds.: Zenke M, Marx-Stölting, L., Schickl, H.), Forschungsberichte der Interdisziplinären Arbeitsgruppen der Berlin-Brandenburgischen Akademie der Wissenschaften, Nomos, Kapitel 3.2.
Carra S, Sangiorgio L, Pelucchi P, Cermenati S, Mezzelani A, Martino V, Palizban M, Albertini A, Götte M, Kehler J, Deflorian G, Beltrame M, Giordano A, Reinbold R, Cotelli F, Bellipanni G, Zucchi I. (2018) Zebrafish Tmem230a cooperates with the Delta/Notch signaling pathway to modulate endothelial cell number in angiogenic vessels.J Cell Physiol. Feb;233(2):1455-1467.
Goetzke R, Franzen J, Ostrowska A, Vogt M, Blaeser A, Klein G, Rath B, Fischer H, Zenke M, Wagner W. (2018) Does Soft Really Matter? Differentiation of Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells is Not Influenced by Soft Hydrogels. Biomaterials, Feb;156:147-158.
Franzen J, Zirkel A, Blake J, Rath B, Benes V, Papantonis A, Wagner W.(2018) Senescence-Associated DNA Methylation is Stochastically Acquired in Subpopulations of Mesenchymal Stem Cells. Aging Cell, Feb;16(1):183-191.
Pachernegg S, Eilebrecht S, Eilebrecht E, Schöneborn H, Neumann S, Benecke AG, Hollmann M. (2018) The siRNA-mediated knockdown of GluN3A in 46C-derived neural stem cells affects mRNA expression levels of neural genes, including known iGluR interactors.PLoS One. Feb 13;13(2):e0192242.
Ventura Ferreira MS, Bienert M, Müller K, Rath B, Goecke T, Opländer C, Braunschweig T, Mela P, Brümmendorf TH, Beier F, Neuss S. (2018) Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.Stem Cell Res Ther, Feb 5;9(1):28.
de Boni L, Gasparoni G, Haubenreich C, Tierling S, Schmitt I, Peitz M, Koch P, Walter J, Wüllner U, Brüstle O. (2018) DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling. Clin Epigenetics. Jan 29;10:13.
Koldehoff M, Lindemann M, Ross SR, Elmaagacli AH (2018) Cytomegalovirus induces HLA-class-II-restricted alloreactivity in an acute myeloid leukemia cell line. PLoS One. Jan 29;13(1):e0191482.
Münst S, Koch P, Kesavan J, Alexander-Mays M, Münst B, Blaess S, Brüstle O. (2018) In vitro segregation and isolation of human pluripotent stem cell-derived neural crest cells. Methods. Jan 15;133:65-80.
Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. (2018) Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.Glia. Jan;66(1):145-160.
Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C (2018) Growth factor independence 1b. A key player in the genesis and maintenance of acute myeloid leukaemia and myelodysplastic syndrome.Haematologica. Jan 11; 103(4):614-25.
Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulus KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Liebermann S, Kreines F, Shono F, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA (2018) Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. Nature Medicine. Jan 08; 24(2):239-46.
Rolfes V, Bittner U, Fangerau H (2018): Die bioethische Debatte um die Stammzellforschung: induzierte pluripotente Stammzellen zwischen Lösung und Problem? In: Zenke M, Marx-Stölting L, Schickl H (eds): Stammzellforschung: Aktuelle wissenschaftliche und gesellschaftliche Entwicklungen. Nomos, Baden-Baden, S. 153-178, erschienen Januar 2018.

2017

Rolfes V, Gerhards H, Opper J, Bittner U, Roth PH, Fangerau H, Gassner UM, Martinsen R (2017). Diskurse über induzierte pluripotente Stammzellforschung und ihre Auswirkungen auf die Gestaltung sozialkompatibler Lösungen – eine interdisziplinäre Bestandsaufnahme. Jahrbuch für Wissenschaft und Ethik 22:65-86.
Kubaczka C, Kaiser F, Schorle H. (2017) Breaking the first lineage barrier - many roads to trophoblast stem cell fate.Placenta. Dec;60 Suppl 1:S52-S56.
Leiendecker A, Schulze M, Tobiasch E, Witzleben S. (2017) Template-mediated Biomineralization for Bone Tissue Engineering. Special issue: Nanobiomaterials for improving stem cell applications in tissue engineering and regenerative medicine.Curr Stem Cell Res Ther. 12(2):103-123.
Pfützner A, Schipper D, Pansky A, Kleinfeld C, Roitzheim B, Tobiasch E. (2017) Mesenchymal Stem Cell Differentiation into Adipocytes Is Equally Induced by Insulin and Proinsulin In Vitro.Int J Stem Cells. Nov 30;10(2):154-159.
Klein D, Steens J, Wiesemann A, Schulz FC, Kaschani F, Roeck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer J, Stuschke M, Jendrossek V (2017) Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression. Antioxid Redox Signal. 26(11):563-582.
Steens J, Zuk M, Benchellal M, Bornemann L, Teichweyde N, Hess J, Unger K, Görgens A, Klump H, Klein D (2017) In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells. Stem Cell Reports. 8(4): 919–932.
Ju Lee H, Bartsch D, Xiao C, Guerrero S, Ahuja G, Schindler C, Moresco JJ, Yates JR 3rd, Gebauer F, Bazzi H, Dieterich C, Kurian L, Vilchez D (2017) A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nat Commun. Nov 13;8(1):1456.
van de Kamp J, Paefgen V, Wöltje M, Böbel M, Jaekel J, Rath B, Labude N, Knüchel R, Jahnen-Dechent W, Neuss S. (2017) Mesenchymal stem cells can be recruited to wounded tissue via hepatocyte growth factor-loaded biomaterials.J Tissue Eng Regen Med. Nov;11(11):2988-2998.
Klapper SD, Sauter EJ, Swiersy A, Hyman MAE, Bamann C, Bamberg E, Busskamp V (2017) On-demand optogenetic activation of human stem-cell-derived neurons. Sci Rep. Oct 31;7(1):14450.
Reinhard J, Roll L and Faissner A (2017) Tenascins in retinal and optic nerve neurodegeneration.Front Integr Neurosci. Oct 23;11:30.
Petri RM, Hackel A, Hahnel K, Dumitru CA, Bruderek K, Flohe SB, Paschen A, Lang S, Brandau S. (2017) Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.Stem Cell Reports. Sep 12;9(3):985-998.
Antal A, Alekseichuk I, Bikson M, Brockmöller J, Brunoni AR, Chen R, Cohen LG, Dowthwaite G, Ellrich J, Flöel A, Fregni F, George MS, Hamilton R, Haueisen J, Herrmann CS, Hummel FC, Lefaucheur JP, Liebetanz D, Loo CK, McCaig CD, Miniussi C, Miranda PC, Moliadze V, Nitsche MA, Nowak R, Padberg F, Pascual-Leone A, Poppendieck W, Priori A, Rossi S, Rossini PM, Rothwell J, Rueger MA, Ruffini G, Schellhorn K, Siebner HR, Ugawa Y, Wexler A, Ziemann U, Hallett M, Paulus W (2017). Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines. Clin Neurophysiol; 128(9): 1774-1809
König L, Kasimir-Bauer S, Bittner AK, Hoffmann O, Wagner B, Manveiler LFS, Kimmig R, Horn PA, Rebmann V (2017) Elevated levels of extracellular vesicles are associated with therapy failure and disease progression in breast cancer patients undergoing neoadjuvant chemotherapy. OncoImmunology. 7:1, e1376153.
Abagnale G, Sechi A, Steger M, Zhou Y, Kuo CC, Aydin G, Schalla C, Müller-Newen G, Zenke M, Costa IG, van Rijn P, Gillner A, Wagner W. (2017) Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies. Stem Cell Reports, Aug 8; 9(2): 654–666.
Koch, P., Ladewig, J. (2017) A little bit of guidance: Mini brains on their route to adolescence. Cell Stem Cell. Aug 3;21(2):157-158.
Jungverdorben J, Till A, Brüstle O. (2017) Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. J Mol Med (Berl). Jul;95(7):705-718.
Wagner W. (2017) Epigenetic aging clocks in mice and men. Genome Biol, Jun 14;18(1):107.
Faissner A, Roll L, and Theocharidis U (2017) Tenascin-C in the matrisome of neural stem and progenitor cells.Mol Cell Neurosci Jun;81:22-31.
Kehler J, Greco M, Martino V, Pachiappan M, Yokoe H, Chen A, Yang M, Auerbach J, Jessee J, Götte M, Milanesi L, Albertini A, Bellipanni G, Zucchi I, Reinbold RA, Giordano A.(2017) RNA-Generated and Gene-Edited Induced Pluripotent Stem Cells for Disease Modeling and Therapy.J Cell Physiol. Jun;232(6):1262-1269.
Schuler PJ, Brandau S. (2017) Adenosine Producing Mesenchymal Stem Cells. Stem Cells. Jun;35(6):1647-1648.
Kandasamy M, Roll L, Langenstroth D, Brüstle O, Faissner A. (2017) Glycoconjugates reveal diversity of human neural stem cells (hNSCs) derived from human induced pluripotent stem cells (hiPSCs). Cell Tissue Res. Jun;368(3):531-549.
Siegel G, Gerber H, Koch P, Brüstle O, Fraering PC, Rajendran L. (2017) The Alzheimer's disease y-secretase generates higher 42:40 ratios for ß-amyloid than for p3 peptides. Cell Rep. Jun 6;19(10):1967-1976.
Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R. (2017) Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. Brain. Jun 1;140(6):1561-1578.
Ulc A, Gottschling C, Schäfer I, Wegrzyn D, van Leeuwen S, Luft V, Reinhard J and Faissner A (2017) Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system plasticity.Biol Chem. May 1;398(5-6):663-675.
Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS.(2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.Matrix Biol. May;59:3-22.
Roese-Koerner B, Stappert L, Brüstle O. (2017) Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Neurogenesis. May 12;4(1):e1313647.
De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brüstle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolén G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE.. (2017) Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.Stem Cell Res. Apr;20:105-114.
Gabriel E, Gopalakrishnan J (2017) Generation of iPSC-derived human brain organoids to model early neurodevelopmental disorders. J Vis Exp. Apr 14;(122).
Iefremova V, Manikakis G, Krefft O, Jabali A, Weynans K, Wilkens R, Marsoner F, Brändl B, Müller FJ, Koch P, Ladewig J (2017) An organoid-based model of cortical development identifies non-cell-autonomous defects in Wnt signaling contributing to Miller-Dieker Syndrome. Cell Reports. Apr;19 (1):50–59.
Akkermann R, Beyer F, Küry P. (2017) Heterogeneous populations of neural stem cells contribute to myelin repair.Neural Regen Res. Apr;12(4):509-517.
Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K. (2017) Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies.Stem Cells. Apr;35(4):859-871.
Schipper D, Babczyk P, El-Sayed F, Klein SE, Schulze M, Tobiasch E. (2017) The Effect of Nanostructured Surfaces on Stem Cell Fate. In “Nanostructures for Novel Therapy”. Editors: A. M. Grumezescu, D. Ficai. Elsevier.
Hansen B, El-Sayed F, Tobiasch E, Witzleben S, Schulze M. (2017) Functionalized 3D Scaffolds for Template-Mediated Biomineralization in Bone Regeneration. In “Frontiers in Stem Cell and Regenerative Medicine Research”. Editors: Atta-ur-Rahman and Shazia Anjum. Bentham Science Publishers. Vol. 5, 130-178.
Sallouh M, Jarocki M, Sallouh O, Degen P, Faissner A and Weberskirch R (2017) The Synergistic Effect of Cationic Moieties and GRGDSF-Peptides in Hydrogels on Neural Stem Cell Behavior.Macromol Biosci. Mar;17(3).
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. (2017) Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proc Natl Acad Sci U S A. Mar 14;114(11):E2243-E2252
Ibrahim SA, Gadalla R, El-Ghonaimy EA, Samir O, Mohamed HT, Hassan H, Greve B, El-Shinawi M, Mohamed MM, Götte M. (2017) Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways.Mol Cancer. Mar 7;16(1):57.
Reinhard J, Renner M, Wiemann S, Shakoor DA, Stute G, Dick HB, Faissner A and Joachim SC (2017) Ischemic injury leads to extracellular matrix alterations in retina and optic nerve.Sci Rep. Mar 6; 7:43470.
Hallmann AL, Araúzo-Bravo MJ, Mavrommatis L, Ehrlich M, Röpke A, Brockhaus J, Missler M, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H, Hargus G. (2017) Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Sci Rep. Mar 3;7:42991.
Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen O, Gopalakrishnan J. (2017) Recent Zika virus isolates induce premature differentiation of neural progenitors in human brain organoids.Cell Stem Cell Mar 2;20(3):397-406.e5.
Tornero D, Tsupykov O, Granmo M, Rodriguez C, Grønning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brüstle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z. (2017) Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli. Brain. Mar 1;140(3):692-706.
Badenes SM, Fernandes TG, Miranda CC, Pusch-Klein A, Haupt S, Rodrigues CAV, Diogoa MM, Brüstle O, Cabrala JMS (2017) Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. J Chem Technol Biotechnol. 92(3):492-503.
Kather M, Skischus M, Kandt P, Pich A, Conrads G, Neuss S. (2017) Functional isoeugenol-modified nanogel coatings for design of biointerfaces.Angew Chem Int Ed, Feb 20;56(9):2497-2502.
Demuth HU, Dijkhuizen RM, Farr TD, Gelderblom M, Horsburgh K, Iadecola C, Mcleod D, Michalski D, Murphy TH, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Saur D, Savitz SI, Schilling S, Spratt NJ, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M, Boltze J (2017) Recent progress in translational research on neurovascular and neurodegenerative disorders. Restor Neurol Neurosci; 35(1): 87-103.
Pelusi N, Kosanke M, Riedt T, Rösseler C, Seré K, Li J, Gütgemann I, Zenke M, Janzen V, Schorle H. (2017) The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm.Sci Rep. Jan 27;7:41427.
Doerr J, Schwarz MK, Wiedermann D, Leinhaas A, Jakobs A, Schloen F, Schwarz I, Diedenhofen M, Braun NC, Koch P, Peterson DA, Kubitscheck U, Hoehn M, Brüstle O. (2017) Whole-brain 3D mapping of human neural transplant innervation. Nat Commun. Jan 19;8:14162.
Lam RS, Töpfer FM, Wood PG, Busskamp V, Bamberg E (2017) Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures. PLoS One. Jan 4;12(1):e0169506.
Reinartz R, Wang S, Kebir S, Silver DJ, Wieland A, Zheng T, Küpper M, Rauschenbach L, Fimmers R, Shepherd TM, Trageser D, Till A, Schäfer N, Glas M, Hillmer AM, Cichon S, Smith AA, Pietsch T, Liu Y, Reynolds BA, Yachnis A, Pincus DW, Simon M, Brüstle O, Steindler DA, Scheffler B. (2017) Functional subclone profiling for prediction of treatment-induced intra-tumor population shifts and discovery of rational drug combinations in human glioblastoma. Clin Cancer Res. Jan 15;23(2):562-574.

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