Stem Cell Biology and Cellular Engineering

Prof. Dr. Dr. Wolfgang Wagner

Institute for Biomedical Engineering – Cell Biology

Uniklinik RWTH Aachen

Website Publications

Our research focusses on the molecular mechanisms that determine cell fate decisions of human stem cells. Focus is on human hematopoietic stem cells, mesenchymal stromal cells, and induced pluripotent stem cells. We characterize how epigenetic changes are acquired during differentiation and how differentiation is regulated by external stimuli. We are particularly interested in the following aspects: (i) Aging and replicative senescence of stem cells;(ii) Characterization of mesenchymal stromal cells for tissue engineering; (iii) Characterization of hematopoietic stem cells; (iv) Mechanobiology and 3D niche modeling; (v) Epigenetic changes in leukemia and cancer-associated fibroblasts; and (vi) Development of epigenetic biomarkers for diagnostics.

Tags:  Hematopoietic Stem Cells  Mesenchymal Stem Cells  Induced Pluripotent Stem Cells  Blood  Bone & Cartilage  Reprogramming  Tissue Engineering  Bioinformatics  Stem Cell Niche  Biomaterials  Aging  Genome Editing  Epigenetics  Translational Research  Biomarker