WG Therapy Resisting Malignant Stem Cells

Our research group focuses on the mechanisms that support the survival and therapy resistance of malignant stem cells (Cancer Stem Cells, CSC) in various hematological neoplasms. These malignant stem cells are characterized by their ability to self-renew, similar to healthy hematopoietic stem cells (HSC). Due to these self-renewal mechanisms and their persistence, even independently of oncogenic stimuli, they pose a significant challenge for targeted therapies.

To identify specific resistance mechanisms, we use various stem cell-based models, including primary patient samples and complex preclinical systems of the bone marrow niche. With these models, we evaluate innovative therapeutic approaches and test their effectiveness in the targeted elimination of resistant stem cell populations. Our goal is to develop new therapeutic strategies through a deep understanding of stem cell-specific resistance, thereby laying the foundation for sustainable improvement in the treatment of hematological neoplasms.