WG Proteostasis of Aging and Stem Cells

Our laboratory seeks to understand how protein homeostasis (proteostasis), epigenetic alterations, post-transcriptional modifications and cell non-autonomous responses modulate stem cell function, cell-fate decisions, organismal aging, and the onset of age-related neurodegenerative diseases to uncover mechanisms of regeneration and multi-disease prevention. To address this ambitious task, we use an innovative approach that combines state-of-the-art proteomics, human stem cell research, iPSC-disease modelling and genetics in the model organism C. elegans as well as plants.