WG Proteostasis of Aging and Stem Cells

Prof. Dr. David Vilchez

CECAD Integrated Stress Response Signaling

Faculty of Medicine, University of Cologne

Website Publications

Our laboratory seeks to understand how protein homeostasis (proteostasis), epigenetic alterations, post-transcriptional modifications and cell non-autonomous responses modulate stem cell function, cell-fate decisions, organismal aging, and the onset of age-related neurodegenerative diseases to uncover mechanisms of regeneration and multi-disease prevention. To address this ambitious task, we use an innovative approach that combines state-of-the-art proteomics, human stem cell research, iPSC-disease modelling and genetics in the model organism C. elegans as well as plants.

Tags:  Neural Stem Cells  Induced Pluripotent Stem Cells  Embryonal Stem Cells  Nervous System  Reprogramming  Organoids  Disease Modelling  Aging  Epigenetics