Tissue Regeneration and Disease Modeling Group

Dr. Dr. Tomo Šarić

Institute for Neurophysiology

University of Cologne

Website Publications

The overall aim of the group is to explore the potential of pluripotent stem cell (PSC) derivatives for tissue regeneration and in vitro disease modelling. In particular, we focus on cardiac repair and aim at enhancing the long-term functional integration of ESC and iPSC-derived cardiomyocytes (CMs) in the infarcted heart, understanding the immunological properties of PSC-CMs, and developing clinically compatible technologies for non-invasive tracking of transplanted cells. In our iPSC-based disease modelling projects we focus on inherited cardiomyopathies. The goal of these model systems is to elucidate the mechanism of disease and ultimately develop safer and more effective therapies for these incurable disorders. To this end, the group has contributed more than 70 disease-specific and control iPSC lines to the “European Bank of induced Pluripotent Stem Cells (EBiSC) within a collaborative project that was funded by the Innovative Medicines Initiative (IMI).

Tags:  Mesenchymal Stem Cells  Neural Stem Cells  Induced Pluripotent Stem Cells  Embryonal Stem Cells  Nervous System  Heart  Reprogramming  Disease Modelling  Preclinical Trials  Genome Editing  Transplantation  Biomarker