Stellate Cells and Liver Regeneration

Prof. Dr. Dieter Häussinger

Clinic of Gastroenterology, Hepatology and Infectious Diseases

Heinrich Heine University Düsseldorf

Website Publications

Stellate cells from liver and pancreas were identified as mesenchymal stem cells (MSC) by our group. The functions of stellate cells during liver homeostasis and regeneration are widely unknown and represent, therefore, our major research topic. Moreover, our group discovered that the space of Disséin liver sinusoids serves as a stem cell niche for stellate cells. The analysis of interactions of stellate cells with their microenvironment or niche is another central aspect of our research. Especially molecular mechanisms that preserve the quiescent state or initiate the activation and control further development of stellate cells are of interest. The findings obtained for stellate cells are also experimentally transferred to iMSC that derive from iPSC, to enable translational research by providing a basis for the development of therapeutic strategies to treat liver diseases using MSC.

Tags:  Mesenchymal Stem Cells  Induced Pluripotent Stem Cells  Pancreas  Liver  Reprogramming  Tissue Engineering  Stem Cell Niche  Biomaterials  Aging  Genome Editing  Epigenetics