Organoid Biology Laboratory

Our lab focusses on established murine lung organoid models derived from stem cells to study development and disease. Our bronchioalveolar organoids organize spatially in bronchiolar and alveolar regions making it the first murine multicellular, differentiated lung organoid system able to recapitulate the cellular composition and architecture of the lung. Building on this model, we established a microinjection technique to generate murine immune-competent lung organoids to investigate the cellular crosstalk between the epithelial-mesenchymal-myeloid unit during lung injury and repair. Our group has also generated diverse organoid systems derived from human iPSC cell lines including blood vessel, lung, and bone marrow organoids. In summary, our laboratory's overarching objective is to establish and apply advanced murine and human immune in vitro models to uncover novel immune cell-specific molecular signaling pathways implicated in disease and regeneration.