Oligodendrocytes in Health and Disease

Oligodendrocytes are the myelinating cells of the CNS. In many CNS diseases, such as multiple sclerosis or leukodystrophies oligodendrocytes are destroyed resulting in demyelination and impaired neuronal function. The Kuhlmann lab studies the molecular mechanisms underlying loss of oligodendrocytes as well as de- and remyelination. The aim of our research is to contribute to a better understanding of CNS diseases and the development of new treatment strategies for demyelinating diseases.