Prof. Dr. Angelika Lampert

Institute for Physiology

Uniklinik RWTH Aachen

Website Publications

Our group focusses on the molecular basis of the origin of peripheral pain, especially when caused by mutations in voltage-gated sodium channels. This channel is responsible for the fast upstroke of the action potential and thus neuronal excitability. We use induced pluripotent stem cells from patients suffering from chronic, inherited pain syndromes and differentiate them into sensory neurons. With patch-clamp, multi-electrode arrays, immunocytochemistry and molecular biological methods, we use this translational cell model to investigating basic mechanisms of development of peripheral pain and possible therapeutic options.

Tags:  Neural Stem Cells  Induced Pluripotent Stem Cells  Nervous System  Reprogramming  Biomaterials  Disease Modelling  Translational Research