Neural Stem Cell Lab

Prof. Dr. Dr. Maria Adele Rüger

Department of Neurology

University Hospital Cologne

Website Publications

Our group’s scientific focus lies on the modulation of endogenous neural stem cells‘ (eNSC) regenerative capacities in vitro and in vivo: Both mobilization and activation of eNSC are directed by a complex cross-talk with local immune cells – microglia – whose activating and functional state depend on the onset and type of neural damage. Elucidating the multi-facetted cell-to-cell communication between the neighbouring cerebral cell entities, we aim at establishing potential therapeutic interventions directly on eNSC and, moreover, at developing pro-regenerative pharmacological procedures to interfere with microglial cell modulation. In this context, we consolidate our expertise in transcranial direct current stimulation (tDCS) for a better understanding of its neurobiological impacts on central nervous cell types and their immunomodulatory interactions.

Tags:  Neural Stem Cells  Nervous System  Tissue Engineering  Stem Cell Niche  Biomaterials  Disease Modelling  Preclinical Trials  High Resolution Imaging