Prof. Dr. Andreas Reichert
The research interests of our group aim towards a fundamental understanding of the role of mitochondria in physiological and pathophysiological situations. In particular, we focus on the molecular mechanisms of mitochondrial dynamics, mitochondrial quality control (mQC) via mitophagy, and mitochondrial ultrastructure (cristae and crista junction formation). The mitochondrial network represents a highly dynamic system and is characterized by continuous fusion and division events. Loss of fusion capacity of damaged mitochondria allows the elective degradation by mitophagy. This is an important mechanism of mQC and disruption of the same, as well as concomitant accumulation of damaged mitochondria, has been shown to play a role in the development of diverse diseases. In the GRK2578, we specifically aim to investigate the role of mitochondria and metabolism in stem cells and the respective differentiated cells derived thereof. In particular, the extent to which genotoxic substances and mitochondria influence the stage of pluripotency and the differentiation process is of major interest to us.