Mitochondrial Biology (WG Reichert)

Prof. Dr. Andreas Reichert

Institute of Biochemistry and Molecular Biology I

Heinrich-Heine University Düsseldorf

Website Publications

The research interests of our group aim towards a fundamental understanding of the role of mitochondria in physiological and pathophysiological situations. In particular, we focus on the molecular mechanisms of mitochondrial dynamics, mitochondrial quality control (mQC) via mitophagy, and mitochondrial ultrastructure (cristae and crista junction formation). The mitochondrial network represents a highly dynamic system and is characterized by continuous fusion and division events. Loss of fusion capacity of damaged mitochondria allows the elective degradation by mitophagy. This is an important mechanism of mQC and disruption of the same, as well as concomitant accumulation of damaged mitochondria, has been shown to play a role in the development of diverse diseases. In the GRK2578, we specifically aim to investigate the role of mitochondria and metabolism in stem cells and the respective differentiated cells derived thereof. In particular, the extent to which genotoxic substances and mitochondria influence the stage of pluripotency and the differentiation process is of major interest to us.


Tags:  Induced Pluripotent Stem Cells  Embryonal Stem Cells  Blood  Heart  Disease Modelling  Aging  High Resolution Imaging  Drug Screening/Discovery