Mesenchymal Stromal Cells in Bone Tissue Engineering

We analyze the mechanisms of the osteogenic and chondrogenic differentiation of mesenchymal stromal cells (MSC). The MSC were isolated from various tissues, for e. g. adipose tissue, bone marrow, or the skin. One research focus is the comparative characterization and impact of reactive oxygen species on the osteogenic differentiation in the context of aging. Furthermore, in our clinic we have established an animal model for evaluating the osteogenic potential of diverse MSC in vivo (Jungbluth et al., 2010). So we have already examined the regeneration of human iMSC (coop. Mr. Prof. Dr. Adjaye, Institute for Stem Cell Research and Regenerative Medicine, human BMSC (coop. Mr. Prof. Dr. Meisel, Clinic for Paediatric Oncology, Haematology and Clinical Immunology), and autologous BMSC in our mini-pig-model.