Laboratory for Developmental and Regenerative RNA Biology

Dr. Leo Kurian

Center for Molecular Medicine Cologne/ Institute for Neurophysiology

University of Cologne

Website Publications

Our lab is interested in understanding the basic molecular rules by which a cell defines and maintains its identity and function. Our main focus is on understanding the molecular basis of programming and reprogramming of cell-fate decisions during embryogenesis, homeostasis and aging. Additionally, we focus on devising molecular strategies to ‘hack’ these genetic networks that programs cell-fates to induce regenerative responses upon injury. In this context, we follow the following four main directions:

  1. Long non-coding RNA mediated regulation of cell-fate decisions during development and homeostasis
  2. Conserved metabolic mediators of tissue-specific aging
  3. RNA-regulons mediating cell-fate decisions during cardiac regeneration
  4. Translational control over cell-fate decisions and homeostasis

Tags:  Neural Stem Cells  Induced Pluripotent Stem Cells  Embryonal Stem Cells  Nervous System  Heart  Kidney  Reprogramming  Developmental Biology  Bioinformatics  Organoids  Aging  High Resolution Imaging  Genome Editing  Epigenetics  Translational Research