
Research
Laboratory for Developmental and Regenerative RNA Biology
Dr. Leo Kurian
Center for Molecular Medicine Cologne/ Institute for Neurophysiology
University of Cologne
Our lab is interested in understanding the basic molecular rules by which a cell defines and maintains its identity and function. Our main focus is on understanding the molecular basis of programming and reprogramming of cell-fate decisions during embryogenesis, homeostasis and aging. Additionally, we focus on devising molecular strategies to ‘hack’ these genetic networks that programs cell-fates to induce regenerative responses upon injury. In this context, we follow the following four main directions:
- Long non-coding RNA mediated regulation of cell-fate decisions during development and homeostasis
- Conserved metabolic mediators of tissue-specific aging
- RNA-regulons mediating cell-fate decisions during cardiac regeneration
- Translational control over cell-fate decisions and homeostasis
Tags: Neural Stem Cells Induced Pluripotent Stem Cells Embryonal Stem Cells Nervous System Heart Kidney Reprogramming Developmental Biology Bioinformatics Organoids Aging High Resolution Imaging Genome Editing Epigenetics Translational Research
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