A growing number of technologies allow for the genome-scale measurement of biological properties such as protein and mRNA concentrations or phenotypic changes. Our Group studies the relationships between proteins and other biomolecules (e.g. DNA, RNA) in silico to reveal the regulatory context of relevant genes.
This work is facilitated by a tight network of experimental collaborators, together with whom we specifically design experiments for our computational analysis. In a collaboration with the Leeb laboratory from Vienna (MFPL) we aim to identify processes and molecular mechanisms required to exit the pluripotent state in embryonic stem cells. Insights from this systems-level approach of the cell fate decision can expand the knowledge of differentiation in embryonic stem cells.