Cell Biology

Our research focuses on the biology and signaling of the transcription factor NF-kB, a key player in neuroprotection, (neuro-) inflammation, stem cell proliferation and cancer formation. We are interested in understanding the role of NF-kB in the proliferation and differentiation of human adult stem cells in the context of clinical applications. We are currently investigating these research topics using adult human neural crest-derived stem cells and with a particular focus on their neuronal and osteogenic differentiation. We are also interested in the role of NF-κB in cancer stem cells from various human cancers. Our research on cancer stem cells also aims to develop new strategies against cancer using immunotherapy.