A primary focus of the research in our laboratory is to define the molecular mechanisms controlling the properties, expression and function of different ion channels that underlies action potentials in normal as well as abnormal conditions, such as those encountered clinically. Moreover, investigators in our laboratory use a sophisticated combination of techniques to define the molecular correlation and functional expression of ion channels in healthy and diseased conditions.
Key objectives of our work are:
- to raise the culture of ES/iPS cell-derived cardiomyocytes and the preparation of heart slices making them acceptable for cell-based therapies
- to understand the molecular mechanisms and functional expression of ion channels and pathways involved in the physiological regulation of cardiac function
- to elucidate the molecular mechanisms by which ion channels and receptors regulate cardiomyogenesis
- to understand the consequences of the coupling between ion channels and signaling pathways in cardiac cells destiny (in vitro)
- to realize the potential of normal and specific mutation carrying pluripotent stem cell-derived cardiomyocytes in drug screening and
- to study the electrophysiological integration of in vitro transplanted cardiomyocytes and their responses to drug exposure.