Inhibitory neurons derived from induced pluripotent stem cells (blue: cell nucleus; red: inhibitory neurotransmitter; green: neuronal marker) [Copyright: Institute of Reconstructive Neurobiology, UK Bonn]
The Ministry of Culture and Science of the State of North Rhine-Westphalia (MKW) provided start-up financing for the promotion of interdisciplinary and cross-location projects in the network.
Here you can find out which projects have been funded since 2005:
The Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers again with 100.000 Euro.
| Principle Investigator | Partner | Project Title |
|---|---|---|
| Mónica Sofia Ventura Ferreira, Rheinisch-Westfälische Technische Hochschule Aachen | Nachwuchsförderung | Dissecting the interaction between macrophages and erythroblasts in the erythroblastic island for a better understanding of erythropoiesis in health and disease |
| Boris Greber, Max-Planck-Institut für molekulare Biomedizin | Dennis Schade, Technische Universität Dortmund | Identifizierung molekularer Werkzeuge zur Expansion früher hPSC-abgeleiteter Kardiomyozyten |
| Bernd Giebel, Universitätsklinikum Essen | Julia Fischer, Universitätsklinikum Bonn | Analyse zellulärer Mechanismen der immunmodulierenden und neuroprotektiven Wirkung von extrazellulären Vesikeln aus neuralen Stammzellen |
| Jonas Doerr, Universitätsklinikum Bonn | Dirk Wiedermann, Max-Planck-Institut für Stoffwechselforschung; | |
| Friedrich Schenk, Fraunhofer-Institut für Produktionstechnologie (IPT) | Dreidimensionale neuroanatomische Darstellung funktioneller Verbindungen transplantierter neuraler Stammzellen anhand multimodaler Messdaten von Lichtscheiben-Mikroskopie, optischer Kohärenztomographie und Magnetresonanztomographie |
Winner projects of the call for translational stem cell research, which are funded until 31.12.2015:
| Funded Project | Institution |
|---|---|
| Fertility of pre-pubertal boys with stem cell defects in testicles | University Hospital Münster |
| StemCellFactory II | University Hospital Aachen, Life & Brain GmbH (Bonn), University Hospital Bonn, Max Planck Institute for Molecular Biomedicine (Münster), Fraunhofer IPT (Aachen), HiTec Zang GmbH (Herzogenrath) |
| Platform Technology Cell Sorter – Upgrade BD FACSAria | University Hospital Essen |
| Stem Cell derived extracellular vesicles | Two clinics of the University Hospital Essen, Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. (Dortmund), Particle Metrix GmbH (Meerbusch) |
| iPS based in-vivo model of human metabolic liver diseases | University Hospital Münster, Max Planck Institute for Molecular Biomedicine (Münster) |
| StemGraft | Miltenyi Biotech GmbH (Bergisch Gladbach), four clinics of the University Hospital Aachen, University Hospital Düsseldorf |
| CardiacDrums | Axiogenesis AG (Köln), Fachhochschule Aachen |
The Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers again with 100.000 Euro.
| Principle Investigator | Partner | Project Title |
|---|---|---|
| Dr. André Görgens, Institut für Transfusionsmedizin, Universitätsklinikum Essen | junior research grant | Identification of multi-potency conserving signal pathways in human hematopoiesis |
| Prof. Dr. Hubert Schorle, Institut für Pathologie, Universitätsklinikum Bonn | Prof. Dr. Martin Zenke, UK RWTH Aachen | Leukemia cells with D816V Kit mutation in vitro and in vivo |
| Dr. Stefan Heinrichs, Institut für Transfusionsmedizin, Universitätsklinikum Essen | Dr. Tom N. Grossmann, Institut für. Chemie und Chemische Biologie, Technische Universität Dortmund | Identification of Mybl2 protein determinants required for the expansion of hematopoietic stem and progenitor cells |
| Prof. Dr. Hendrik Milting, Herz- & Diabeteszentrum NRW, Ruhr-Universiät Bochum | Dr. Dr. Tomo Saric, Institut für Physiologie und Pathophysiologie, Universität Köln | Mechanobiological properties of cardiomyocytes derived from induced pluripotent stem cells of patients afflicted with arrhythmogenic right ventricular cardiomyopathy type 5 caused by a missensemutation in the TMEM43 gene |
| Dr. Nina Graffmann, Institut für Stammzellforschung und Regenerative Medizin, Universität Düsseldorf | Dipl. Molbiomed. Laura Stappert, Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn | Identification of GCNF target genes in human pluripotent stem cells and neural stem cells derived thereof |
The Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers again with 100.000 Euro.
| Principle Investigator | Partner | Project Title |
|---|---|---|
| Dr. Paola Koenen. IFOM, University Witten/Herdecke | junior research grant | Homing of mesenchymal stem cells in acute and chronic wounds |
| Dr. Eva Christine Bunk, Institut für Zellbiologie, Universität Münster | junior research grant | Comparison of the species-specific differences in induction of neuronal und glial differentiation via Prox 1 gene in iPSCs and NSCs from mouse, marmoset and man |
| Dr. Julia Ladewig, Institut for Rekonstruktive Neurobiology, Bonn | junior research grant | Modelling cortical migration defects using patient-specific induced neurons |
| Prof. Dr. Christian Kaltschmidt, LS Zellbiologie, University of Bielefeld | Prof. Dr. Hans Schöler, Max Planck Institute for Molecular Biomedicine, Münster | Reprogramming with microNRW: Role of NF-?B |
| Dr. Jens Benninghoff, Clinic for Psychiatry, LVR Klinikum an der Universität Duisburg-Essen | Philipp Koch, Institut for Rekonstructive Neurobiology, Bonn | Analysis of molecular changes in serotonergic neurotransmission in Bipolar Disease using patient-specific iPS cells |
The State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers in the Stem Cell Network NRW with 200.000 Euro.
| Principal Investigator | Partner | Topic |
|---|---|---|
| Dr. J. Sterneckert, Max-Planck-Institut für molekulare Biomedizin, Münster | junior research grant | Drug discovery for amyotrophic lateral sclerosis using patient-specific human induced pluripotent stem cell based disease modeling |
| Dr. K. Pfannkuche, Institut für Neurphysiologie, Universitätsklinikum Köln | junior research grant | Hochauflösende vergleichende Molekularanalyse von Herzmuskelzellen aus humanen induziert pluripotenten Stammzellen |
| Dr. B. Greber, Max-Planck-Institut für molekulare Biomedizin, Münster | junior research grant | Mechanismen der Mesoderm und Kardiomyozyten-Induktion in hES- und hiPS-Zellen |
| Dr. R. Schneider-Kramann, Institut für Pathologie, Uniklinik RWTH Aachen | junior research grant | Einsatz von reprogrammierten, pluripotenten Stammzellen im Rahmen des Tissue Engineering der Haut: Therapeutische Implikation für Patienten mit chronischen Wunden und genetisch bedingten Hauterkrankungen. |
| Dr. V. Janzen, Med. Klinik II, Hämatologie, Universitätsklinikum Bonn | Prof. Dr. W. Wagner, Helmholtz-Institut für Biomed. Technologie, Uniklinik RWTH Aachen | Bedeutung von Osteopontin für die Regulation der Alterung hämatopoietischer Stammzellen und der Stammzellnische |
| Dr. S. Neuss-Stein, Institut für Pathologie, Uniklinik RWTH Aachen | Dr. T. Saric, Institut für Neurophysiologie, Universitätsklinikum Köln | Kardiomyogene Diffenzierung von gPS-Zellen auf Biomaterialien |
| PD Dr. A. von Holst, Institut für Zellmorphologie und molekulare Neurobiologie, Ruhr-Universität Bochum | Prof. Dr. S. Ergün, Institut für Anatomie, Universitätsklinikum Essen | Human vascular wall-resident stem cells and neural differentiation |
| Dr. P. Koch, Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn | PD. B. Giebel, Institut für Transfusionsmedizin Universitätsklinikum Essen | Asymmetric cell division of human neuroepithelial-like stem cells |
The State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers in the Stem Cell Network NRW with 120.000 Euro.
| Principal Investigator | Partner | Topic |
|---|---|---|
| Dr. Jens Christian Schwamborn, Stemcellbiology and Regeneration, Münster | junior research grant | Reprogramming of ependymal cells in neural stem cells: in vitro andin vivo. |
| Prof. Hubert Schorle, Developmental Pathology, Bonn | Prof. Stefan Schlatt, Center for Reproductive Medicine and Andrology, University Münster | Developmental and oncogenic potential of TCam-2, a human PGC-like cell line |
| Dr. Sabine Neuß-Stein, Institute of Pathology, University Hospital Aachen | junior research grant | Microsphere-based, directed Differentiaton of iPS- und gPS-Cells |
| Dr. Tamara Glaser, Prof. Dr. Oliver Brüstle, Institute of Reconstructive Neurobiology, Bonn | Prof. Dr. Andreas Faissner, Faculty for Cellmorphology and Molecular Neurobiology | Generation of gliogenic neural stem cells from human ES cells and epitope-based lineage selection of oligodendrocytes |
| Dipl. Biol. Nina Kossack, Centrum für Reproduktionsmedizin und Andrologie, Universität Münster | junior research grant | Generation and characterization of human spermatogonial stem cell lines |
| Dr. Ursula Theocharidis, LS für Zellmorphologie und Molekulare Neurobiologie, Ruhr-Universität Bochum | junior research grant | Regulatory control of the neural stem cell niche |
| Diana Klein, Universitätsklinikum Essen | junior research grant | Local Progenitors in the Vascular Wall: MSC-derived pericytes in vascular morphogenesis |
| Dr. rer. nat. Carsten Berndt, Universitätsklinikum Düsseldorf | junior research grant | Thioredoxins and glutaredoxins - small molecules on the crossing of stem cell profileration and differentiation |
The State of North Rhine-Westphalia funds transregional and interdisciplinary projects in the Stem Cell Network NRW with 100.000 Euro.
| Principal Investigator | Partner | Topic |
|---|---|---|
| Prof. Dr. Martin Zenke Department of Cell Biology, Institute for molecular Biomedicine, RWTH Aachen | Prof. Dr. Hans Schöler, Max-Planck-Institut für molekulare Biomedizin, Münster | Cellular Memory in Pluripotent ES Cell/Hematopoietic Stem Cell Hybrids |
| Dipl. Biol. Kurt Pfannkuche, Prof. Jürgen Hescheler, Institute for Neurophysiology, University of Cologne | Prof. Dr. Peter Dröge, School of Biological Sciences, Singapur | Generation of stable pluripotent cell-lines from reprogrammed fibroblasts (iPS cells) and evaluation of their cardiac differentiation potential |
| Prof. Dr. Sigrid Nikol Molecular Cardiology, Medical Clinic C, University Clinic of Münster | Prof. Dr. Hans Schöler Max Planck Institute for molecular Biomedicine, Münster | Derivation of endothelial (progenitor) cells from pluripotent germline stem cells |
| PD Dr Frank Edenhofer Institute for Reconstructive Neurobiology, Bonn University | Prof. Dr. Karl Friehs Technical Faculty, Bielefeld University | Large-scale-production of cell-permeable proteins for pluripotency induction in somatic cells |
| Prof. Dr. Gesine Kögler, Prof. Dr. Peter Wernet, Institute for Transplantation Diagnostics and Cell Therapeutics, University of Duesseldorf | Prof. Dr. Hans Schöler, Dr. Holm Zaehres, Max-Planck-Institute for molecular Biomedicine, Münster | Reprogramming of human cord blood populations to pluripotent stem cells with defined transcription factors and small molecules |
The state of North Rhine-Westphalia has provided 80.000 Euro for the funding of interdisciplinary and joint projects.
| Principal Investigator | Partner | Topic |
|---|---|---|
| Dr. Johannes Fischer und Dr. Bernd Giebel Institut für Transplantationsdiagnostik und Zelltherapeutika, Düsseldorf | Dr. Bernd Denecke Interdisziplinäres Zentrum für Klinische Forschung (IZKF) BIOMAT, RWTH Aachen | Einfluß unterschiedlicher Biomaterialien auf das ex vivo Wachstum endothelialer Vorläuferzellen (endothelial colony-formig cells (ECFCs)) |
| Prof. Dr. Oliver Brüstle Institut für Rekonstruktive Neurobiologie, Bonn | Prof. Dr. Peter Wernet Institut für Transplantationsdiagnostik und Zelltherapeutika, Düsseldorf | Analysis of microRNA expression in pluripotent and multipotent human stem cells |
| Prof. Dr. Hubert Schorle Abteilung Entwicklungsbiologie, Institut für Pathologie, Bonn | Prof. Dr. Hans Schöler Max-Planck-Institut für molekulare Biomedizin, Münster | The role of AP-2gamma in controlling germ cell differentiation |
Again four projects of interdisciplinary character have been chosen for public funding of 75.000 Euro in addition.
| Principal Investigator | Partner | Topic |
|---|---|---|
| Prof. Dr. Hubert Schorle Dept. Developmental Pathology, Bonn | Dr. Andrea Vortkamp ZMB Developmental Biology, Duisburg-Essen | The role of PDGFR a in controlling osteoprogenitor cells |
| Dr. med. dr. sci. Tomo Saric Institute for Neurophysiology, Cologne | Prof. Dr. Jürgen Hescheler, Institute for Neurophysiology, Cologne; Prof. Dr. Bernd Fleischmann Life & Brain Center, Bonn | Generation of a transgenic human embryonic stem cell line for Cardio- myocyte selection and characterization of their immunologic properties in vivo upon transplantation into mice reconstituted with the human immune system |
| Prof. Dr. Thomas Noll Institut für Zellkultur-Technologie | Prof. Dr. Christian Kaltschmidt Institut für Neurobiochemie Universität Witten/Herdecke | Culture of human somatic periodontal stem cells in a bioreactor for therapy of periodontitis |
| Dr. Thomas Hieronymus Institute for Biomedical Engineering - Cell Biology, Aachen | Dr. Uwe Himmelreich In-vivo-NMR Laboratory, Max-Planck-Institut für Neurologische Forschung, Köln | Magnetic resonance imaging of hematopoietic stem-/progenitor cell migration and differentiation in vivo using sm |
This year four interdisciplinary projects have been selected and are provided with 100.000 Euro.
| Principal investigator | Partner | Topic |
|---|---|---|
| Prof. Dr. Elke Winterhager, Institut für Anatomie, Universitätsklinikum Essen | Prof. Dr. Hubert Schorle, Abteilung Entwicklungspathologie, Universitätsklinikum Bonn | The role of AP-2 in trophectoderm stem cell maintenance with special focus on its potential downstream target connexin 31 |
| Prof. Dr. med Sigrid Nikol, Medizinische Klinik und Poliklinik C, Universitätsklinik Münster | Prof. Dr. rer. nat. Hans Schöler, Max Planck Institut für Molekulare Biomedizin, Münster | Testis-derived ES-like cells for the regenerative treatment of myocardial infarction and heart failure |
| Dr. rer. nat. Tino Polen | gesamtes KNW | NRW Stem Base |
| Prof. Dr. Oliver Brüstle, Institut für Rekonstruktive Neurobiologie, Universität Bonn | Dr. rer. nat. Thomas Noll, Institut für Biotechnologie 2, Forschungszentrum Jülich | Expansion of Pluripotent Stem Cells in a Small Scale Cultivation System with Oxygen and pH Control |
c/o Life Science Center
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D 40225 Düsseldorf
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